panaceachronicles

Pure, Natural Coca Leaf – A Healing Gift Of The Divine Plant


Leave a comment

Prostate Cancer & Tobacco Pesticides: The Hidden Connection

There doesn’t seem to be any question about the connection between pesticide exposure of agricultural workers and prostate cancer. We know that this kind of exposure leads to prostate cancer, and we know which pesticides are the causal agents.

Through new research that we have just completed, we can also now identify specific pesticides that are known to cause prostate cancer that contaminate specific tobacco products. This means that a whole new connection between smoking and prostate cancer starts to emerge. 

We can see that specific pesticide contaminants of tobacco products are the same pesticides that have been shown to cause prostate cancer in exposed farm workers. (I discuss farm worker exposure vs smoker exposure below.)

Check out this data from lab tests we’ve just finished running on off-the-shelf tobacco products. Notice the totally illegal and banned worldwide DDT. Notice all the Azole fungicides like Penconazole. Check that amazing concentration of Cypermethrin. But really, with 0.816 mg/kg of DDT in every puff, all day every day, what other direct linkages to prostate cancer would you need? How about that 0.843 mg/kg of Carbenzadim, banned in the EU since 2014.

We are sadly confident that the entire tobacco product supply in the US will prove to be similarly heavily contaminated. We plan to test as many brands as possible as soon as funding becomes available. But here’s what we’ve found so far.

Community Tobacco Control Partners Test Results 12/18

Farm workers are exposed heavily to known prostate carcinogens regularly during certain parts of the year, whereas smokers of the brands shown above are inhaling known prostate carcinogens 50-100 times a day and more, year-round. So we are looking at two kinds of exposure – heavy during the season for farm workers, and low-level 7/365 for smokers. Intermittent mid-level exposure vs chronic low-level exposure. Also the farm workers are being exposed to one chemical at a time where the smoker is getting a toxic cocktail. Then of course there are farm workers who smoke the cheap tobacco brands like little cigars because that’s all they can afford. Double or triple whammy there. 

One thing that needs special attention with this new connection is the clear evidence that a smoker with prostate cancer risks that cancer turning very aggressive if it feeds on DDT and other endocrine-disrupting pesticides, which we can now show are just what that aggressive cancer is getting with every puff. Doctors see this happen in relapsing patients and know that it’s connected with their smoking but can’t explain why it’s happening. 

Here’s the message: If you stop feeding that thing in your prostate the chemicals that turn it aggressive maybe it will calm down and maybe you and the docs can get it under control.

So, here are a few key references. There are plenty more – it just depends on how much convincing anyone needs.

Rev Environ Health. 2016 Sep 1;31(3):311-27

Exposure to pesticides and prostate cancer: systematic review of the literature.

Results: The review included 49 studies published between 1993 and 2015. All studies were in English and analyzed exposure to pesticides and/or agricultural activities. Most studies (32 articles) found a positive association between prostate cancer and pesticides or agricultural occupations, with estimates ranging from 1.01 to 14.10.

So, what if tobacco products were loaded with pesticides but nobody knew about that contamination, so even though they knew there was a link between smoking and prostate cancer they didn’t know why? Would that show up in smoking & prostate cancer studies? Well, it seems that it might.

Eur Urol Focus. 2015 Aug;1(1):28-38.

Smoking and Prostate Cancer: A Systematic Review

CONCLUSIONS:

Data from the peer-reviewed literature suggested an association of smoking and aggressive PCa. Although the pathophysiology underlying this association remains unclear, smokers presented higher PCa mortality and worse outcome after treatment. Smoking-cessation counseling should be implemented for patients with PCa, although its effect on PCa progression should be investigated.

OK, but how do we know that the pesticides in tobacco products have anything to do with prostate cancer? Well, first, pesticides used in tobacco are heavily used throughout agriculture. Second, we know that at least two of the contaminants of the little cigar we tested are potent human carcinogens and one acts specifically on human testicles. Now your testicles aren’t your prostate, but that’s getting close enough to merit a second glance if you’re a smoker, don’t you think?

https://pubchem.ncbi.nlm.nih.gov/compound/Carbendazim#section=GHS-Classification

“Carbendazim is a broad-spectrum benzimidazole antifungal with potential antimitotic and antineoplastic activities. Although the exact mechanism of action is unclear, carbendazim appears to binds to an unspecified site on tubulin and suppresses microtubule assembly dynamic. This results in cell cycle arrest at the G2/M phase and an induction of apoptosis.”

Oh, and that other carcinogen – the one that directly impacts your prostate?

Chemico-Biological Interactions

Volume 230, 25 March 2015, Pages 40-49

p,p′-Dichlorodiphenyltrichloroethane (p,p′-DDT) and p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) repress prostate specific antigen levels in human prostate cancer cell lines

“Thus, we conclude that men who have been exposed to either DDT or DDE may produce a false-negative PSA test when screening for prostate cancer, resulting in an inaccurate clinical diagnosis. More importantly, prolonged exposure to these anti-androgens may mimic androgen ablation therapy in individuals with prostate cancer, thus exacerbating the condition by inadvertently forcing adaptation to this stress early in the disease.”

These are farmers, not smokers, but their prostate didn’t like the DDT exposure and neither will the prostate of anyone who inhales pesticide-contaminated tobacco product smoke (or vapor).

Prostate. 2011 Feb 1;71(2):168-83.

Prostate cancer risk and exposure to pesticides in British Columbia farmers.

“The significant association between prostate cancer risk and exposure to DDT (OR = 1.68; 95% CI: 1.04-2.70 for high exposure), simazine (OR = 1.89; 95% CI: 1.08-3.33 for high exposure), and lindane (OR = 2.02; 95% CI: 1.15-3.55 for high exposure) is in keeping with those previously reported in the literature.

If you keep smoking things just get worse; if you quit after 10 years the risk disappears. But if you are going to keep smoking at least pay attention to the pesticides that you’re inhaling and choose the least contaminated brand possible.

European Urology, December 2015, Volume 68, Issue 6, Pages 949–956

Association of Cigarette Smoking and Smoking Cessation with Biochemical Recurrence of Prostate Cancer in Patients Treated with Radical Prostatectomy

We investigated the effect of smoking on the risk of prostate cancer recurrence in patients with treated with surgery. We found that former smokers and current smokers were at higher risk of cancer recurrence compared to patients who never smoked; the detrimental effect of smoking was mitigated after 10 yr or more of smoking cessation.

I’m not writing this post as a science paper – I’m writing it to point out a connection that is as obvious as it is hidden, and hoping that the message will reach people who can benefit. The message to smokers is that if you are going to smoke, pay close attention to the contaminants in your brand and stop feeding your cancer with banned pesticides. I know this is heresy but – if you’re going to keep smoking than at least smoke American Spirit organic tobacco. Fair disclosure – I invented American Spirit but lost the company to the tobacco industry not long after we started and I have absolutely no connection of any kind to the company. I don’t benefit in any way from anyone choosing American Spirit. Well, actually, the benefit I get is the only one I want, which is knowing that I may have made a contribution to the health and happiness of another person.

 


Leave a comment

Dude! That Shit’s Shrinking Your Balls!

Does your kid, or a kid who you know and care about smoke little cigars or some other kind of cheap, flavored tobacco? Are you frustrated because you can’t stop them? Do they have a major “don’t give a shit” attitude? Even if they are being little idiots, do you understand and still want to help?

I propose some evidence-based reality and an appeal to that little idiot’s well-concealed intelligence. Do you think you can you get this kid to sit with you for one hour and read this post together. In the post I will lay out hard evidence showing how their testicles and genetic materials (and those of their friends) are under stealth chemical attack from contaminated cheap products they are being suckered into smoking. Challenge yourselves to understand the science and read through the references together – they are linked to the original research. This isn’t obscure science – this is about clear evidence of specific chemicals known to attack male reproductive organs in the tobacco brand they smoke that are there because of a cheap, money-grubbing manufacturer’s carelessness and greed. See if your discussion doesn’t trigger an instinct for self-preservation in them and maybe even a clue.

We all know that “please please don’t smoke” doesn’t work, and neither does “smoking is really really bad for you”.  How many millions of dollars are still being wasted on endless repetition of some version of those two “nanny state” themes? Tell a kid that there are 4000 really really bad chemicals in that cigarette, or that he’s going to get lung cancer, and he will sneer to show you how tough he is. Tell him that the cheap-ass manufacturer of that crap he’s smoking is using trash tobacco that’s such shitty stuff that it’s contaminated with totally illegal chemicals that are attacking his balls every time he takes a hit. Tell him that the brands that are poisoned this way are pushed hard to people in poor neighborhoods who can only afford cheap poisoned shit, and to people who have enough money to afford less poisoned brands but are too stupid to know the difference. Show him the data tables below and ask him what he thinks – which brands are pushed to which people in which neighborhoods? Point out, in case he doesn’t get it, that when it comes to tobacco shit definitely rolls downhill.  

BTW this post is for boys. I’m working on one for girls that will be titled “Girl – Those Swisher Things Are Frying Your Eggs!”

So young Dude, you smoke Swisher Sweets. Maybe some other brands too. Lots of people love to smoke Swisher Sweets, especially when they see hotties like Carly B sucking on their favorite kind of Swisher. But those Swisher Sweets aren’t anything like what the Man behind Carly B. wants you to think they are. No indeed.

Dude, no joke – your balls are at serious risk smoking that shit. If you’re cool with that, no problem. It’s your life. But, for the sake of those who care about you, take a little time and think about a couple of things.

Let’s begin with a reality check on those sweet fruity little cigars. Do you think you’re going to get real tobacco at 2 sticks that weigh 3 grams each for $0.99? Really? Then you must have bought your share of baggies of Oregano thinking you were getting bargain dope, because the math doesn’t work. Even if they didn’t shrivel your nuts, little cigars are not real tobacco. They are worse trash than any toxic Mexican weed you ever smoked, even when you weren’t buying Oregano, and here’s why. Those little 3 gram sticks are made especially for poor kids and stupid kids and are loaded with chemicals that do all kinds of nasty shit, but only to the people who smoke the cheap stuff. Most of those chemicals aren’t even there in the pricier brands, and Swisher Sweet smokers and little cigar smokers in general get special treatment as you can see here. This data is from tests we just ran on off-the-shelf tobacco products popular with young smokers from all kinds of communities.

Community Tobacco Control Partners Test Results 12/18

Keep your eye on that Carbendazim under “Swisher Sweets” in the right-hand column because that’s the ball-shrinker we’re talking about. I’m going to explain the connection in a minute.

To be fair you have to ask why those friendly folks at Swisher Sweet would want to bother to shrink your balls? Well, they don’t actually. They don’t care about your balls, or the kids you may want to make someday with those balls. All they’re doing is spraying their tobacco fields with chemicals that kill off the bugs more effectively by shrinking adult bug balls so they can’t have baby bugs. It’s a new way of controlling bugs, and they will tell you they have to do it. You just can’t kill bugs with pure poisons anymore – they’ve gotten resistant. But their little balls are vulnerable as hell, and that’s what these chemicals are designed to attack and destroy, so you add chemicals like Carbendazim to your chemical cocktail and wham – no bugs, and a lot more valuable tobacco per acre.

OK, bugs don’t have balls, not little ones hanging on the outside anyway, but they do have male reproductive organs and those are what Carbendazim targets. 

But, unfortunately, those chemicals the manufacturers use in their tobacco fields don’t only bust bug balls, they twist and shrink the balls of every critter they touch, like human Swisher Sweet smokers. That would be you, young Dude, wouldn’t it? Well hey, as long as you keep buying that shit and smoking it what do they care about you and your precious little balls? Nobody says it’s illegal for them to have ball-busting chemicals in their little cigars so why worry about it – they keep the bugs from eating all those valuable tobacco leaves that the companies sell in premium brands while poor folks and kids stupid enough to think they’re getting a sweet deal get to smoke the trash the bugs leave behind.

OK, this has all been trash talk. Now I’m going to assume that you understand regular English and basic science. I’m also going to assume that if you’ve read this far maybe you’re ready for some straight talk, and that you may, secretly even, be starting to give a shit. So here’s just a taste of the straight science behind your shrinking balls in regular English, with links for you to follow and make up your own mind what you’re going to do about it. 

This first reference just about says it all for any young man who smokes little cigars and expects to have children:

Why Carbendazim has been banned in the EU since 2014

Then there are all these peer-reviewed scientific findings:

“Although the exact mechanism of action is unclear, carbendazim appears to bind to an unspecified site on tubulin and suppresses microtubule assembly dynamic. This results in cell cycle arrest at the G2/M phase and an induction of apoptosis.(translation: it shrinks your balls.)

The Link: https://pubchem.ncbi.nlm.nih.gov/compound/Carbendazim#section=GHS-Classification

“The fungicide Carbendazim Methyl-2-benzimidazole carbamate (MBC) is known to produce male reproductive toxicity.” (translation: there is no doubt.)

The Link: https://www.ncbi.nlm.nih.gov/pubmed/17479253?dopt=Abstract

“Administration of carbendazim induced significant decrease in testis weight, diameter, and germinal epithelial height of the seminiferous tubules. Histological results revealed degeneration of seminiferous tubules, loss of spermatogenic cells, and apoptosis.

Moreover, carbendazim caused elevation of testicular malondialdehyde (MDA), marker of lipid peroxidation, and reduced the activity of the antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT).” (translation: it shrinks them and totally fucks them up.) 

The Link: https://www.ncbi.nlm.nih.gov/pubmed/22903170?dopt=Abstract

“2,5-Hexanedione (2,5-HD), a taxol-like promoter of microtubule assembly, and carbendazim (CBZ), a colchicine-like inhibitor of microtubule assembly, are two environmental testicular toxicants that target and disrupt microtubule function in Sertoli cells.” (translation: testicle toxins work together.) 

The Link: https://www.ncbi.nlm.nih.gov/pubmed/15141104?dopt=Abstract

“Due to synergistic effects, low environmentally present concentrations of imazalil and cypermethrin in food, and especially their mixtures with carbendazim have genotoxic potential that could be particularly dangerous over prolonged exposure in mammalian organism.”(translation: prolonged exposure destroys the genetic materials in your balls.) 

The Link:  https://www.ncbi.nlm.nih.gov/pubmed/21868589?dopt=Abstract

If you want to read more on other linkages between pesticide contamination of tobacco products and disease please follow these links to other recent posts:

Obesity & Obesogens: The Toxic Chemical Connection

https://wp.me/p48Z9A-nJ4

Tobacco Pesticides & Childhood Leukemia

https://wp.me/p48Z9A-nIL

Tobacco Road – Brazilian Tobacco, Nerve Agents, and American Cigarettes

https://wp.me/p48Z9A-nyp

DDT, Little Cigars, & Dropouts

https://wp.me/p48Z9A-nIk

Organic Tobacco Is Safer Tobacco & Here’s Why

https://wp.me/p48Z9A-nH5

Do You Want To Make Little Cigars Illegal In Your Community?

https://wp.me/p48Z9A-nEY

Smoking & Health – Fake Science Kills

https://wp.me/p48Z9A-nxW


Leave a comment

Tobacco Pesticides & Childhood Leukemia

PestGroup01

Community Tobacco Control Partners Test Results 12/18

Heavy concentrations of pesticide residues in cheap tobacco products being smoked by mothers, fathers or others in the household are likely to be a factor in the high rates of childhood Leukemia (ALL) among Hispanic and Native American children. I believe these hidden, unregulated pesticides will prove to be be a major factor in childhood cancer, once their presence and nature is recognized. Simply controlling pesticide residues in tobacco products by imposing reasonable standards on manufacturers would lower the incidence of childhood cancer, perhaps dramatically, in certain groups of people.

The reason this hasn’t been realized is that:

  1. While the link between pesticide exposure of the fetus and development of childhood Leukemia (ALL) is proven, and;

  2. While parental smoking and childhood Leukemia are strongly associated, and;

  3. While Hispanic and Native American children are proven to have higher rates of ALL and;

  4. While marginalized young people are heavy consumers of the cheapest tobacco products, driven by price and attracted by fruity sweet flavors and targeted social media marketing, nevertheless;

  5. None of the researchers knew that tobacco products, and particularly those smoked and preferred by young Hispanics and Native Americans, are heavily contaminated with the kinds of pesticides that are known to cause ALL, and;

  6. Although researchers say that they can see clearly that pesticides, smoking and ALL are linked, they can’t explain the connections.

Here is what they do know (journal citations are below the narrative).

  1. In addition to Hispanic and Native American children having higher rates of childhood leukemia (ALL) than other groups, research shows that children with at least 10% Native American ancestry have 59% higher relapse rates after being “cured” of ALL the first time.

  2. Childhood Leukemia is known to be initiated by pesticide exposure at specific points in fetal development. There are other causes, but the wrong kind of pesticide exposure at the wrong time initiates genetic processes leading directly to childhood Leukemia.

  3. The relationship between fetal pesticide exposure and increased likelihood of childhood Leukemia in Hispanic and Native American children is proven. The multiple causes of ALL are not clear to researchers, but the associations with pesticides are strong.

Here’s what we think is going on.

We believe that our new data on pesticide contamination of tobacco products offers a novel and powerful explanation for the association between parental smoking and childhood Leukemia in Hispanic, Native American and other vulnerable populations.

We have just completed our first tests of off-the-shelf tobacco products for pesticide residues (12/18). We randomly selected samples from a universe of tobacco products known to be popular with young smokers.

  1. The pesticides that we identified contaminating tobacco products marketed to and smoked by poor, young non-white people included multiple heavy concentrations of specific pesticides that are known to initiate childhood leukemia disproportionately in Hispanic and Native American babies.

  2. A significant proportion of young, low-income Hispanics and Native Americans smoke little cigars, and because this is a very heavily contaminated tobacco product category, their children are exposed beginning with conception to xenobiotics that are known pathways to childhood leukemia and that show particular virulence in Hispanic and Native American children. Little cigars are by no means the only pesticide-contaminated tobacco products – they are simply the most contaminated of any that we have been able to test so far.

  3. Because childhood Leukemia is known to initiate its growth at specific developmental stages, chronic smoking of tobacco products containing high concentrations of pesticides by the pregnant mother, or by anyone in the household, guarantees that xenobiotics will be present at every critical point for the initiation of development of childhood Leukemia in the growing child.

  4. Since pesticide exposure levels required for initiation of disease processes during fetal development can be very low, concentrations remaining in second-hand smoke might be sufficient to initiate these disease-inducing genetic changes in the fetus even when the pregnant woman does not smoke.

But it’s not just pregnant mothers and smoking family members who give babies Leukemia. A new relationship has just been established between smoking by Hispanic fathers and leukemia in their children. 

Pesticide contamination of the products that young Hispanic fathers are smoking appears to be a novel, powerful and unrecognized connection between their smoking and childhood Leukemia in their children. These findings are further reinforced by recent findings of paternal smoking influence in childhood Leukemia in a non-Hispanic White Australian population. It is therefore highly likely that this link applies to Native American fathers as well.

See for yourself what the research says. Here are some of the core research articles that I believe support a clear link between contaminated tobacco products and childhood Leukemia. 

Linking Pesticide Exposure with Pediatric Leukemia: Potential Underlying Mechanisms

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848917/

Leukemia is the most common cancer in children, representing 30% of all childhood cancers. The disease arises from recurrent genetic insults that block differentiation of hematopoietic stem and/or progenitor cells (HSPCs) and drives uncontrolled proliferation and survival of the differentiation-blocked clone. Pediatric leukemia is phenotypically and genetically heterogeneous with an obscure etiology.

The interaction between genetic factors and environmental agents represents a potential etiological driver. Although information is limited, the principal toxic mechanisms of potential leukemogenic agents (e.g., etoposide, benzene metabolites, bioflavonoids and some pesticides) include topoisomerase II inhibition and/or excessive generation of free radicals, which may induce DNA single- and double-strand breaks (DNA-DSBs) in early HSPCs.

Chromosomal rearrangements (duplications, deletions and translocations) may occur if these lesions are not properly repaired.

The initiating hit usually occurs in utero and commonly leads to the expression of oncogenic fusion proteins. Subsequent cooperating hits define the disease latency and occur after birth and may be of a genetic, epigenetic or immune nature (i.e., delayed infection-mediated immune deregulation).

Here, we review the available experimental and epidemiological evidence linking pesticide exposure to infant and childhood leukemia and provide a mechanistic basis to support the association, focusing on early initiating molecular events.”

Paternal smoking and risk of childhood acute lymphoblastic leukemia: systematic review and meta-analysis.

https://www.ncbi.nlm.nih.gov/pubmed/21765828

(Ed. Note: the authors of the study mean “parental”, not “paternal”.)

OBJECTIVE:

To investigate the association between paternal smoking and childhood acute lymphoblastic leukemia (ALL).

METHOD:

We identified 18 published epidemiologic studies that reported data on both paternal smoking and childhood ALL risk. We performed a meta-analysis and analyzed dose-response relationships on ALL risk for smoking during preconception, during pregnancy, after birth, and ever smoking.

RESULTS:

The summary odds ratio (OR) of childhood ALL associated with paternal smoking was 1.11 (95% Confidence Interval (CI): 1.05-1.18, I(2) = 18%) during any time period, 1.25 (95% CI: 1.08-1.46, I(2) = 53%) preconception; 1.24 (95% CI: 1.07-1.43, I(2) = 54%) during pregnancy, and 1.24 (95% CI: 0.96-1.60, I(2) = 64%) after birth, with a dose-response relationship between childhood ALL and paternal smoking preconception or after birth.

CONCLUSION:

The evidence supports a positive association between childhood ALL and paternal ever smoking and at each exposure time period examined. Future epidemiologic studies should assess paternal smoking during well-defined exposure windows and should include biomarkers to assess smoking exposure and toxicological mechanisms.

Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia

http://cancerres.aacrjournals.org/content/early/2017/03/22/0008-5472.CAN-16-2571

“In summary, we provide evidence that increased tobacco smoke exposure increases the generation of somatic ALL-associated driver deletions. To our knowledge, this is also the first reported application of an epigenetic biomarker to assess the effects of an environmental exposure on leukemogenic alterations.”

“Our findings should be added to an already compelling list of reasons for minimizing the prenatal and early life tobacco smoke exposure of children.” 

Childhood Leukemia Incidence in California: High and Rising in the Hispanic Population

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542672/

“Ethnic disparities in children’s exposure to chemicals at home, as well as ethnic disparities in their parents’ exposures to chemicals at work, may contribute to the higher burden of childhood leukemia in Hispanic children.

A more complete evaluation of the role of specific environmental factors that disproportionally affect the Hispanic community in the increased risk of leukemia in Hispanic children is warranted.”

Native American ancestry linked to greater risk of relapse in young leukemia patients

https://www.sciencedaily.com/releases/2011/02/110206132908.htm

The study found that ALL cancer was 59 percent more likely to return in patients whose genetic makeup reflected at least 10 percent Native American ancestry.

Investigators also found ALL patients with greater Native American ancestry who received additional chemotherapy as part of a COG clinical trial benefited more from the extra treatment than other children.

In utero pesticides exposure and generation of acute myeloid leukemia associated translocation (8;21)

https://medcraveonline.com/MOJT/MOJT-02-00037.pdf

 The present study was set to detect t (8;21) translocation in umbilical cord blood samples from neonates as in utero primary molecular hit in the pathway of childhood leukemia in apparently healthy neonates and to delineate the relationship between generation of this translocation and prenatal pesticide exposure.

Four pesticides were studied including Malathion and Diazinon as organophosphates, and DDT and Lindane as organochlorines. The choice of these four pesticides was based on their popular use in the community under investigation and their well-established role in cancer pathology.”

“Of the studied pesticides, DDT was accompanied by highest risk for carrying the fusion Oncogene [OR 3.55 (95%CI 1.53-8.26), P=0.003].”

“Since pediatric leukemia involves both genetics and environmental interactions, pesticides provide a perfect link in such regard. In this relatively large study we report on a direct relation of prenatal Malathion and DDT exposure and the incidence of leukemia translocation in neonates.”

“To the best of our knowledge, the current study is the first study to evaluate the effect of pesticides on acquiring AML fusion Oncogene in Egypt, where the analyzed Xenobiotics are still used and not banned yet.”  (Published November 28, 2016)

In Utero Pesticide Exposure and Leukemia in Brazilian Children < 2 Years of Age

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569673/

 “Our findings suggest that children whose mothers were exposed to pesticides 3 months before conception were at least twice as likely to be diagnosed with ALL in the first year of life compared with those whose mothers did not report such exposure.

Adjusted ORs for AML in the first year of life ranged from 2.75 (95% CI: 0.96, 7.92) for any pesticide exposure in the first trimester of pregnancy, to 7.04 (95% CI: 2.47, 20.10) for exposure during breastfeeding.

Studies conducted in other countries have also reported positive associations between pesticide exposure and hematopoietic neoplasms in children, especially leukemias and lymphomas (Ma et al. 2002Meinert at al. 2000Menegaux et al. 2006Rudant et al. 2007Zahm and Ward 1998).

A systematic review and meta-analysis of 15 studies of the association between residential exposure to pesticides during selected time windows (preconception, pregnancy, and childhood) and childhood leukemia carried out during 1950–2009. (Turner et al. 2010) reported associations with pregnancy exposure to unspecified pesticides (OR = 1.54; 95% CI: 1.13, 2.11), insecticides (OR = 2.05; 95% CI: 1.80, 2.32), and herbicides (OR = 1.61; 95% CI: 1.20, 2.16).

Another meta-analysis of 31 studies of parental occupational exposure to pesticides and childhood leukemia (Wigle et al. 2009) reported associations with occupational exposure to insecticides (OR = 2.72; 95% CI: 1.47, 5.04) and herbicides (OR = 3.62; 95% CI: 1.28, 10.3) during pregnancy.

A French study also examined the association between pesticide exposure and infant leukemia (Rudant et al. 2007). According to use of any pesticide, the observed risk estimates (ORs) were 2.3 (95% CI: 1.9, 2.8) for ALL and 2.2 (95% CI: 1.4, 3.3) for AML. These authors also suggested that a domestic use of pesticides may play a role in the etiology of leukemia, and that prenatal exposure may be a window of fetal vulnerability.

Incidence rates of childhood leukemia in the United States have steadily increased over the last several decades, but only recently have disparities in the increase in incidence been recognized.

Trends in Childhood Leukemia Incidence Over Two Decades from 1992–2013

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550103/

In the current analysis, Surveillance, Epidemiology and End Results (SEER) data were used to evaluate recent trends in the incidence of childhood leukemia diagnosed at age 0–19 years from 1992–2013, overall and by age, race/ethnicity, gender, and histologic subtype. Hispanic White children were more likely than non-Hispanic White, non-Hispanic Black or non-Hispanic Asian children to be diagnosed with acute lymphocytic leukemia (ALL) from 2009–2013.

From 1992–2013, a significant increase in ALL incidence was observed for Hispanic White children (annual percent change (APC)Hispanic=1.08, 95%CI:0.59, 1.58); no significant increase was observed for non-Hispanic White, Black or Asian children.

ALL incidence increased by about 3% per year from 1992–2013 for Hispanic White children diagnosed from 15–19 years (APC=2.67; 95%CI:0.88, 4.49), and by 2% for those 10–14 years (APC=2.09; 95%CI:0.57, 3.63), while no significant increases in incidence were observed in non-Hispanic White, Black, or Asian children of the same age.

Acute myeloid leukemia (AML) incidence increased among non-Hispanic White children under 1 year at diagnosis, and among Hispanic White children diagnosed at age 1–4. The increase in incidence rates of childhood ALL appears to be driven by rising rates in older Hispanic children (10–14, and 15–19 years).


2 Comments

Organic Tobacco Is Safer Tobacco & Here’s Why

Community Tobacco Control Partners Test Results 12/18

I’m getting more than a little tired of hearing the too-clever bullshit from self-serving agencies like FDA and from anti-smoking hustlers like Truth Initiative claiming that organic cigarettes aren’t safer than regular commercial cigarettes because all tobacco is equally hazardous. That’s either a deliberate lie or gross ignorance. They either actually know nothing about the industry on which they claim great expertise, or they are lying about what they know to cover their years of incompetence and even complicity. 

An Oregon non-profit I started last year just finished testing five brands of tobacco products for pesticide residues, and we found hard evidence of extreme differences between the safety levels of organic tobacco and off-the-shelf mini-mart tobacco products regardless of what you may think about tobacco itself.

What you see above is the first-ever hard data on pesticide residues in regular, commercial tobacco products. See any differences between brands? By the way, what you don’t see here is American Spirit Organic because we tested that and found exactly ZERO pesticide residues.

So please tell me – are there any differences here?

  • Is the least contaminated tobacco product safer than the most contaminated one, or not? 

  • Even if you assume that the tobacco in all three brands is the same, which it isn’t, would you say there are differences in safety levels, or not? 

  • If someone you love is smoking and you can’t get them to stop, which of the three brands above would you want them to smoke, and why?

  • If your kid is sneaking off and smoking, which of these brands would you least want them to be smoking, and why? 

Looking at that hard data, only blind arrogance or a hidden agenda could continue to claim that the DDT, Carbendazim and Penconazole residues in the little cigars that kids are smoking right now, today doesn’t matter because tobacco itself is so bad anyway. Yet that is exactly what EPA, FDA, all the anti-smoking groups, and all the state health departments pretend to believe. That’s their excuse for doing nothing, and it’s pathetic. Here’s why.

Alcohol products are “so bad anyway” and are certainly right up there with tobacco products in terms of the death, disease, personal and social costs and widespread suffering they cause, but you can bet that there would be an “all hands on deck” emergency alarm sent out if even a few of the pesticides we just found in tobacco products were found in beer or wine down at the mini-mart. That contaminated shit would be pulled from the coolers instantly, and there would be lawsuits and congressional investigations. There would be no shrugging of shoulders and saying what the hell, alcohol is so bad for people anyway that a few pesticides don’t matter. 

That may be harsh, but this level of self-serving deceitfulness while enormous numbers of people die from pesticide contaminated tobacco products every year, and while children around the world are sealing their future fates by being lured into smoking these cheap contaminated tobacco products, all of which is 100% preventable, is beyond disgusting. 

We ran our tests on off-the-shelf tobacco products from local mini-marts – exactly what the kids buy and where they buy them. The question we asked ourselves after looking at the results is – if it were possible, wouldn’t the kids smoking this trash, idiots that they certainly are, be safer smoking these products if they were exactly the same crap as they are now but weren’t additionally contaminated with the extremely hazardous pesticides?

We know that 1 in 13 of all the children under 17 alive today will die prematurely, painfully and expensively of “smoking-related” disease. That is a whole lot of children and future suffering.  Do you think any of it could be prevented just by requiring tobacco manufacturers to remove pesticide residues from their tobacco?

They could do that, almost in a flash. Why don’t they? Because they don’t have to, and because it’s much more profitable to use chemicals than to use labor, even in the remote areas of the Third World where they grow their tobacco out of sight of regulators and inspectors.

The fact is that millions of future deaths can very likely be prevented by acting now to set reasonable standards for pesticide residues in tobacco products.  Those standards exist – simply look at Oregon’s pesticide residue “Action Levels” for Cannabis, or the FDA’s own “Action Levels” for DDT in everything but tobacco. Everything.

Every tobacco product on the market could be made with organic tobacco – no problem. Give the industry 3-5 years and a drop-dead set of conditions and they will do whatever they have to do. It would take longer to actually become organic, but in 3-5 years the world tobacco supply could be 75% cleared of pesticide residues.

However as long as “players” like FDA and Truth Initiative and others like them play the “All Tobacco Is Equally Bad” game nothing will change. Of the total number of smokers dying each year, a significant number die because of the arrogant conceit of those who believe (or at least pretend to believe) they know all the truth there is to know about Tobacco when they have never once set foot in any tobacco field anywhere, much less a field that has just been sprayed with DDT in Nicaragua or Brazil. 

And then in 2015 the moralists and parasites had the nerve to go after organic tobacco. The problem is that they apparently don’t know what Tobacco is, or really that much about it, because if they did they wouldn’t have gotten themselves into the really stupid trap of insisting for the record that there’s no difference between organic tobacco and severely contaminated tobacco. They may claim when finally confronted that they don’t know about the pesticides, and maybe I’ll believe them, but probably not.

Of course if they did admit they have known about the pesticides all along then they would also have to admit culpability in 50 years of countless deaths and measureless suffering that could have been completely prevented by insisting on reasonable regulations on pesticide residues in tobacco products. The problem of organochlorine pesticides in heavy concentrations in tobacco products was first realized in the 1950’s, and was heavily documented through the 1960’s. There was testimony before the Senate calling specific attention to the problem. That issue quickly died in the US Senate of 1969.

Then in the 1970’s as smoking and health issues became a major public and scientific concern, the Tobacco industry realized it had a severe problem, and a nationwide lid was clamped on any research referring to pesticides in tobacco products. research continued in other countries and has resulted in strict but reasonable laws regulating pesticide residues in tobacco products. But in the US beginning in the 1970’s what research couldn’t be directly corrupted or subtly misdirected was subverted through strategies like the “Reference Cigarette” program.

That’s quite a few years of preventable deaths that lie at the feet of those who have been so fixed on hating what they believed was Tobacco that they never once stopped to ask if it was actually Tobacco they were hating.

But then in 2015 they scored what they thought was a face-saving victory – they got RJR to go public and say the words – organic tobacco does not mean a safer cigarette. They finally got payback for years of feeling powerless in the face of the whole tobacco industry. unfortunately, we know that FDA was only able to force RJR to agree to their lies because RJR didn’t want to have to defend American Spirit organic by showing WHY American Spirit organic cigarettes are safer. They are safer because they aren’t drenched with pesticides like every other commercial tobacco brand, including every other RJR brand besides organic American Spirit.

Notice that in the data tables below even the regular American Spirit Blue non-organic brand is lower in pesticides than the Maroboro or another RJR brand, Camel. That’s a big difference in safety levels even among non-organic brands, much less between organic and non-organic. However, if RJR had defended American Spirit organic tobacco on that simple evidence-based premise then they would have had to admit how contaminated all their other products are, and why. Oops! That’s a non-starter. Think of the lawsuits!

So it was a much, much better deal for RJR to let FDA pretend they scored a big win, just like years before the Surgeon General’s warnings were a godsend to tobacco manufacturers. It let them say – hey, you were warned. The so-called “Tobacco Settlement” was an even bigger fraud – look at what is actually being done with all that money. Lots of “Tobacco is really really bad” advertising, lots of huge salaries and nice perks, everybody congratulating themselves on what a great job they’re doing, and no change in the numbers of people suffering and dying, or in the number of kids heading down that dead-end road.

Until my little non-profit finally got funding and was able to begin testing tobacco products a few months ago, not one dime has ever been spent by the “anti-tobacco” forces to test for these contaminants that by themselves make these products illegal, period. But then the “Tobacco is really really bad” game would be over, wouldn’t it. Imagine the public reaction if it became clear that people in positions of responsibility and authority had known about pesticide contamination of tobacco products for many smokers’ lifetimes and had never once spoken out.

FDA knows what it has to do in return for being allowed to look like a winner in the organic tobacco derby. Their part of the deal is not to make too much noise about all those “crop protection agents”. That’s what the industry calls pesticides. After all, crops need protection, right? so much better than a nasty word ending in “cide”.

FDA and the anti-tobacco PR and advertising shills are allowed to beat the drums and make up endless variations of the “Tobacco Is So Bad” meme because that doesn’t hurt the tobacco industry one bit, but it does allow thousands of people to keep doing extremely dubious work to justify their lucrative titles and careers “fighting tobacco”.

Ever wonder why FDA is being so helpful in the industry’s pivot away from tobacco and toward e-cigarettes? Are they are all hoping that their complicity in 50 years of slaughter for profit will just slide on out of sight? Yes, complicity. FDA has had institutional knowledge of the presence of heavy concentrations of hazardous pesticides in tobacco products for over 20 years and has not once, ever brought it up in any hearings or testimony or research. That’s complicity.

I call the tobacco industry’s reckless, negligent, criminal behavior “slaughter for profit” simply because the tobacco industry doesn’t have to use pesticides at all. Traditional tobacco growers used hand labor for hundreds of years and did just fine. The tobacco companies use chemicals in place of labor strictly for increased profits and they have rigged the regulatory systems of the world so that they are protected from the consequences of their greed-driven decisions.

No matter. I’m here to call bullshit right now with simple hard evidence. AKA facts. You decide.

Check the data below after you read the following incredible weasel-statements and then you tell me:

Are these bureaucrats full of shit or not?

Are some tobacco products safer than others, or not?

Should people who smoke be protected from these contaminants, or do they deserve whatever happens to them?

If these chemicals were in wine or beer, would that be OK just because alcohol is known to be so hazardous to health anyway.

Does it not matter that the most hazardous of these brands, the one with 375 times the highest background level of DDT, is the one that most kids 11-16 love?

Because use of tobacco products, with or without pesticide residues, is so hazardous to health, all of the Oregon Health Authority’s efforts around tobacco are aimed at discouraging use of tobacco products and encouraging cessation of tobacco use in people already using it.” Oregon Health Authority 2018

“EPA does not assess intermediate or long-term risks of pesticide residues to smokers because of the severity of health effects linked to use of tobacco products themselves.” EPA 2018

“Organic,” “natural” or “additive-free” product labels may imply a healthier or safer choice, but that couldn’t be further from the truth when it comes to tobacco products. A cigarette with organic tobacco or tobacco with no additives does not make it healthier or safer than other cigarettes.” Truth Initiative 2018

No differences at all? Really?

Pesticide Residue Test Sample #1                              Multnomah County, Oregon                                          Received 12/13/2018 

Analyte

Results/Units

Exceeds “Action Level”

Not Registered – Oregon √√

Banned/No Tolerance √√√

American Spirit – USDA Organic (test substrate)

None Detected

0

American Spirit Blue (Cigarette)

Azoxystrobin

0.936 mg/kg

Imidacloprid

0.105 mg/kg

Propamocarb √√

0.252 mg/kg

Fluopyram √√

Trace

Spinosad

Trace

Marlboro Red (Cigarette)

Azoxystrobin

0.897 mg/kg

Bifenthrin

0.0870 mg/kg

Chlorantraniliprole

0.614 mg/kg

Dimethomorph  √√

 0.0220 mg/kg

Metalaxyl

0.0780 mg/kg

Propamocarb √√

0.129 mg/kg

Fluopicolide √√

Trace

Imidacloprid

Trace

Penconazole √√

Trace

Trifloxystrobin

Trace

Camel (Cigarette)

Azoxystrobin

0.875 mg/kg

Chlorantraniliprole

0.377 mg/kg

Dimethomorph √√

0.0210 mg/kg

Imidacloprid

0.106 mg/kg

Metalaxyl

0.0810 mg/kg

MGK-264

0.0600 mg/kg

Propamocarb √√

0.167 mg/kg

Bifenthrin

Trace

Penconazole √√√

Trace

Piperonyl Butoxide

Trace

Swisher Sweet (Little Cigar)

Acetamiprid

0.146 mg/kg

Azoxystrobin

0.198 mg/kg

Carbendazim √√√

0.843 mg/kg

Cypermethrin

0.443 mg/kg

DDT, p,p-  √√√

0.816 mg/kg

Dimethomorph √√

0.0380 mg/kg

Fenamidone √√

0.0370 mg/kg

Imidacloprid

0.169 mg/kg

Indoxacarb √√

0.0790 mg/kg

Mandipropamid √√

0.0770 mg/kg

Pendimethalin √√

0.0910 mg/kg

Propamocarb √√

0.0910 mg/kg

Pyraclostrobin √√

0.0210 mg/kg

Chlorantraniliprole

Trace

Ethofenprox

Trace

MGK

Trace

Permethrin

Trace

Thiacloprid

Trace

Camel (Snus)

Azoxystrobin

0.142 mg/kg

Fluopyram √√

0.0380 mg/kg

Bifenthrin

Trace

Mandipropamide

Trace

Pendimethalin

Trace


Leave a comment

Pure Medical Marijuana & Natural Heirloom Tobacco – A Logical Combination

 

I’ve visited quite a few MM clinics in Oregon and Washington and of course, like so many public venues, these clinics are “Non-Smoking” public spaces. At every one of these clinics I’ve noticed that there were ashtrays at the door, always brimming with discarded cigarette butts. So this says to me that many of the people who are using Marijuana to help them deal with medical issues are also smoking commercial cigarettes. (Duh)
buttz
Although most people, including smokers, know that “cigarettes are bad for you” and that “smoking causes all kinds of nasty diseases”, what few people understand is that virtually all commercial cigarette brands are not manufactured from pure, natural tobacco but rather from industrial materials that vast amounts of money have been spent on to make them look and smoke like what people think of as tobacco. In other words, it is not tobacco that is sickening and killing all those people. If they were smoking pure, natural tobacco few if any of them would have to pay the price that almost every commercial cigarette smoker now pays sooner or later.

I’ve written long and detailed research reports on this topic but, very understandably, few people like to read complex technical materials, so it has been a great frustration to me to try to communicate with cigarette smokers how and why they and all those around them are being poisoned, sickened, and killed so that a murderous industry can thrive.

So I won’t go on and on here either, because I respect your time and don’t want to lose any interest you may have in this subject.

So let me offer you a 30 minute video that I did in the late 1980s which does a pretty good job of laying out the basic information behind the cigarette industry’s criminal behavior – and then let me describe the amazing opportunity that this terrible situation creates for many different sectors of the Medical Marijuana sector.

So, if you have watched this video (thank you), please consider what would happen if the Medical Marijuana community, and especially the Medical Marijuana grower community, decided that we have both the means and the responsibility to grow and produce pure, natural heirloom tobacco products in addition to the high quality Cannabis already being produced for the MM patient community.

smokerWe already have a well-established market, and we have the full confidence of people in that market. If we started selling pure, natural tobacco alongside the pure, natural Cannabis that patients are now buying from us – why wouldn’t most of our patients choose the real thing over industrialized poison. Besides, anyone who enjoys smoking what they think is tobacco now will go absolutely berserk when they get a taste of true, natural tobacco. Believe me – I’ve seen it happen, and it happens every time.

I will be happy to provide growers and entrepreneurs all the information and technical support they would need to get a natural tobacco operation up and running, from choosing which heirloom varieties to grow to the curing, flavoring, processing and small-scale manufacturing of a line of natural tobacco products. This is a project that has been close to my heart for many, many years I would welcome the chance to help to make it happen.

If we act together, we can not only offer safe and effective Cannabis medication & treatment to patients, but also take a huge step toward prevention of many of the conditions and diseases that plague the lives that are being poisoned by this loathsome industry. And we can create enormous business opportunities by doing so.

I know about the business opportunities first-hand. In the early 1980s my friend and partner Robert Marion and I created the Santa Fe Natural Tobacco Company. And I developed the company’s flagship brand American Spirit. But because I was an idiot I lost the company early in its life, but quite a few friends of mine who put $500 or $1000 into SFNT company stock in those early days are now millionaires. I, unfortunately, am not.

So I know the kind of business opportunity that natural tobacco products represent, and I believe strongly that the MM movement is in prime position to create not one, but dozens of natural tobacco products businesses right alongside the MM clinics, dispensaries, and grow-houses that are now flourishing in so much of America.

Many of us in the MM movement are very concerned about the designs that we know the worldwide cigarette industry has on this rapidly growing sector. What better way to cut these criminals off at the knees than to find an effective way to take away a large portion of their customer base?

Yes, there would be obstacles. The federal government would not be a friend – it would be a very active antagonist. The cigarette industry itself controls politicians and regulators at every level of government. But hey – didn’t we just win a huge victory for both medical and recreational marijuana by going up against exactly those kinds of odds and not backing down?

We can do the same thing with natural tobacco that we did with medical marijuana, and we can not only give a lot of people the gift of a healthier lifestyle, we can also be pro-active in fighting off what we know is the coming assault on our new and – let’s admit it – still a little vulnerable MM industry by the cigarette company predators.

Finally, just to be explicit about the role that the Medical Marijuana community can and, IMO, should play in helping patients transition from smoking poisonous industrial waste to smoking pure natural heirloom tobacco, check out this list of the top ten diseases caused by smoking commercial cigarettes – and reflect on how many of these diseases Medical Marijuana is already helping patients deal with.

1. COPD (Chronic Obstructive Pulmonary Disease)
2. Cardiovascular (heart) disease
3. Cancer (lung cancer, esophagus cancer, larynx cancer, mouth cancer, throat cancer, kidney cancer, bladder cancer, pancreas cancer, stomach cancer, cancer of the pancreas, liver cancer, cancer of the penis and cervix cancer)
4. Emphysema
5. Chronic Bronchitis
6. Asthma
7. Stroke
8. Hypertension
9. Atherosclerosis (buildup of fatty substances in the arteries)
10. Impotence
Now I ask you, if Medical Marijuana professionals and entrepreneurs can not only help those who suffer from these diseases to safely and effectively treat and in the case of some of these diseases cure their illness, how much greater impact could we have if we were also instrumental in helping prevent people from getting sick in the first place?

If ever there was an opportunity to do well by doing good, this is it.