CBD, COVID 19 & Cytokine Storms

Sure, let’s find a vaccine for the virus, by all means, but in the meanwhile how about the solid research evidence that CBD can prevent and treat the lung inflammation leading to pneumonia that is killing so many victims? It sure looks to me like there’s no doubt that it is the lung inflammation from COVID 19 that is a major killer and maybe THE major killer.

Here’s new 2020 research that says that the cytokine storms (inflammatory response) resulting from COVID 19 may be doing a lot of the killing.

“Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China”

Intensive Care Medicine (2020)

“In conclusion, predictors of a fatal outcome in COVID-19 cases included age, the presence of underlying diseases, the presence of secondary infection and elevated inflammatory indicators in the blood. The results obtained from this study also suggest that COVID-19 mortality might be due to virus-activated “cytokine storm syndrome” or fulminant myocarditis.”

Now here is a study that specifically addresses the effects of CBD on cytokine storms.

“Cannabinoids Decrease the Th17 Inflammatory Autoimmune Phenotype”

Journal of Neuroimmune Pharmacology 8(5) · July 2013

“Cannabinoids, the Cannabis constituents, are known to possess anti-inflammatory properties but the mechanisms involved are not understood. Here we show that the main psychoactive cannabinoid, Δ-9-tetrahydrocannabinol (THC), and the main non-psychoactive cannabinoid, cannabidiol (CBD), markedly reduce the Th17 phenotype which is known to be increased in inflammatory autoimmune pathologies ….”

“In conclusion, the results show a unique cannabinoid modulation of the autoimmune cytokine milieu combining suppression of the pathogenic IL-17 and IL-6 cytokines along with boosting the expression of the anti-inflammatory cytokine IL-10.”

Before you say “Well hell, that’s only one study from 2013”, check out these other CBD-Inflammation studies from my previous posts.

https://www.ncbi.nlm.nih.gov/pubmed/25356537

Thus, we conclude that CBD administered therapeutically, i.e. during an ongoing inflammatory process, has a potent anti-inflammatory effect and also improves the lung function in mice submitted to LPS-induced ALI. Therefore the present and previous data suggest that in the future cannabidiol might become a useful therapeutic tool for the attenuation and treatment of inflammatory lung diseases.

https://www.ncbi.nlm.nih.gov/pubmed/31437494

Thus, CBD has a differential inflammatory response and acts as an anti-inflammatory agent in pro-inflammatory conditions but acts as an antagonist with steroids, overriding the anti-inflammatory potential of steroids when used in combination.

https://www.ncbi.nlm.nih.gov/pubmed/23851307

Together, our findings highlight the anti-inflammatory effects of CBD in this viral model of MS and demonstrate the significant therapeutic potential of this compound for the treatment of pathologies with an inflammatory component.

https://www.ncbi.nlm.nih.gov/pubmed/30481497

CBD treatment, regardless of dosage, decreased airway hyperresponsiveness, whereas static lung elastance only reduced with high dose. These outcomes were accompanied by decreases in collagen fibre content in both airway and alveolar septa and the expression of markers associated with inflammation in the bronchoalveolar lavage fluid and lung homogenate. There was a significant and inverse correlation between CB1 levels and lung function in asthmatic patients. CBD treatment decreased the inflammatory and remodelling processes in the model of allergic asthma. 

https://www.ncbi.nlm.nih.gov/pubmed/31800399

CBD induced almost full concentration-dependent vasorelaxation in hPAs and rat sMAs. In hPAs,

https://www.ncbi.nlm.nih.gov/pubmed/31775230

The main focus is on the latest in vitro and in vivo studies that present data regarding the anti-proliferative, pro-apoptotic, cytotoxic, anti-invasive, anti-antiangiogenic, anti-inflammatory, and immunomodulatory properties of CBD together with their mechanisms of action. 

Now ask yourself – why wouldn’t anyone at risk be taking 25-50 mg of CBD a day starting right now? Are you? If not, why the hell not?

I do hope you’re not waiting for the government to admit that Cannabis might be a natural medicine that can protect you and those you love, not from getting infected with COVID 19, but maybe from dying from the inflammation that it causes. That is not going to happen, and surely you know why.

 

 

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