Angelo Mariani was without doubt the most successful, and probably the most ethical of all of the 19th Century manufacturers of Coca Leaf-based tonics. Unlike most other manufacturers, of which there were hundreds in Europe and the US, he practiced strict quality control, even to the point of developing proprietary Coca plantations in Peru and Bolivia where his proprietary Coca Leaf was grown, harvested, processed and shipped to Europe under carefully controlled conditions.

In contrast most other tonic manufacturers used cheap, dried-out Coca Leaf scrap that was the reject of Coca harvests in Peru and Bolivia – literally the scrapings from the Coca Leaf processing floors in those countries. And reminiscent of the Cocaine trade today these unscrupulous manufacturers didn’t hesitate to adulterate their products with whatever cheap crap they thought they could get away with to bulk out their products.

In addition, the Bordeaux wine that he used as the base and Coca solvent for his tonic was sourced from several prominent French chateau producers, whereas other manufacturers who tried to copy Mariani’s success used the cheapest red swill they could obtain. Again, exactly the kind of behavior we see in 99% of today’s Cocaine (and Heroin) markets.

As a result Mariani’s tonic delivered the same quality medication to patients from one bottle to the next, and it was also pleasant-tasting, and because of these qualities it remained the premium Coca Leaf tonic on the market for decades both in Europe and North America.

Mariani’s attention to detail, and his energetic marketing, primarily through the publication of testimonials from prominent users of his products worldwide, were responsible for his life-long success and should be studied carefully by entrepreneurs in the Medical Marijuana space today.

In this post you’ll get a sense of how doctors and patients of the late 19th Century viewed Vin Mariani tonic. As you read through these excerpts from their correspondence to Mariani you have to ask yourself – were all these people simply idiots, or were they competent physicians and completely sane patients? It follows that if they were neither insane nor idiots, then perhaps the insane idiots are those who stand in the way of sick people having access to pure, natural Coca Leaf remedies today.

These remedies are certainly available (see this post on medicinal tonics being produced in Bolivia today), and given the outstanding economic success of Medical Marijuana in those US states where it is finally legal, you have to ask yourself “What are we waiting for? Why aren’t we growing Coca and producing Coca Leaf medicines in the US today?”

Here are a few of the testimonials from the files of Angelo Mariani:

Meulan, March 17, 1874.
I wish to inform you that I have nothing but good results to report in all the cases in which I have employed the Vin Mariani in my practice. Yours, very respectfully,
DR. GASTOK MARCEL

Paris, May 12, 1874.
One of my patients, Lady Superior of a convent in the environs of Paris, affected with a profound anemia, which has resisted all treatment, and which, by the long use of iron and quinine, had become complicated with constipation and gastric disturbance, was relieved of the latter symptoms after twenty days’ treatment with Vin Mariani, and under the influence of this same medicine her anemia gradually lessened, and in the course of three months disappeared.
DR. LAVILLE.

10 Rue Castiglione, Paris.
Obliged by professional duties to be continually near sick people, who often do not leave me time to take my meals, I desired to experiment with Coca as an analeptic. My trials have been with Vin Mariani. and here is what I have found :

A Bordeaux-glass full of this wine has always sufficed to make me forget hunger and to sustain my strength. I felt a slight warmth and general toning up of the body; the digestion of the meal which followed was always more easy than when I had not taken the Mariani Wine, and, although I had not a sensation of voracious hunger as I had without it, I ate very well, the stomach appearing more robust and more active.
DR. CHAPUSOT.

La Porta, February 15, 1877.
Having had such splendid results in my practice with the Vin Mariani since a number of years, I counsel you to have your vrine tried in London and New York, for I am persuaded that in all the great centres, where tlio incessant occupation and the abnormal kind of life led there fatally engender anemia, Vin Mariani is able to render the greatest services.
DR. H. CONNEAU,
Member of The Academie de Médicine, formerly Chief Physician of Napoleon III. , Emperor of the French, Grand Officer of the Legion of Honor.

Paris, December, 15 1876.
Since some time I prescribe to my patients Vin Mariani, and, in the cases of gastric trouble and anemia, I have had nothing but praise for the results obtained.
DR. CABANELLAS.

M. Mariani, Paris : London.
Since using your wine my digestion is splendid and my strength is returning. Respectfully,
DR. DELFER.

Paris, January 25, 1876.
M. Mariani, Paris :
“Ne pigeat ex plebeis sciseltari si quid ad curationem utile,” said Hippocrates (in prœceptis), that is to say, let us not disdain popular remedies. It was with eagerness that I welcomed in my practice the Vin Mariani, based upon Peruvian Coca, a plant so popularly used in its native place. I have proved the efficacy of your preparation, which is at the same time useful and agreeable, in cases of nervous over-excitation with sleeplessness, of uni-lateral headaches, in throat diseases accompanied with pain, in spasms of the stomach with intense thirst, and sometimes in bilious vomiting. By re-establishing the digestive functions, Vin Mariani restores the general strength of the organism, and becomes a tonic without having the inconvenience of other medicaments, called tonics, which produce constipation. As the first of all therapeutical rules is, for me, the one well known since Hippocrates, which has been newly brought forward in our days by Hahnemann, under the formula — Similia similibus curantur, I think that the efficacy of Coca, in the affections I have just enumerated, is due to the application of the homœopathic law; and the well-known fact, that the natives deceive their hunger and; calm the cravings of their stomach by chewing and swallowing a substance which habitually increases the appetite, is a confirmation of my idea.
DR. CONQUERET.

New York, August 16, 1884.
I have prescribed the Mariani Wine extensively during the last year, and with very favorable results. Its tonic and stimulant properties are very marked, particularly as manifested in its action on the nervous and muscular systems. It is well borne by even delicate stomachs. In my experience the weaker and more delicate the subject, the more pronounced its action and the more permanent its effects. While not a universal panacea for all the ills of life, it is a very valuable therapeutic agent, and certainly possesses most of the properties claimed for it.
E. S. BATES, M.D.
161 E. 31st Street, New York.

New York, February 5, 1884.
Dear Sir : — I have examined morphologically your Mariani Wine, and also have tested it on patients, and I can cordially recommend it as being up to its standard, and of utility in cases where wine and Coca are indicated. Yours very truly,
EPHKAIM CUTTER, M.D.

Fayetteville, N. C, February 21, 1884.
Messrs. Mariani & Co., New York,
Dear Sirs : — I find Vin Mariani a most excellent – in fact, an indispensable – remedy in nervous debility. A patient of mine, a constant sufferer in this way, experiences immediate and absolute relief by the use of Mariani’s Wine, while nothing else affords him the least comfort. Your preparation of the diug cannot be too highly recommended.
Yours truly, H. W. LILLY, M.D.

London, November 9, 1882.
M. Mariani :
At the special recommendation of Dr. Lennox Browne, of London, I have tested carefully the Vin Mariani, and I recognize that its splendid effect upon the voice is extremely satisfactory, and almost instantaneous. For over two years I have tried it, ordering it to my pupils, both ladies and gentlemen, whom I had under my care for the development of the voice, and I have invariably remarked that, whenever they had any difficulty in singing or elocution, the Vin Mariani enabled them to continue the lesson, •which, without it, would have been utterly impossible. I have thus every reason to be glad that my attention was called to this remarkable preparation, and am convinced that all artists and orators will welcome it and be happy to adopt it.
PROFESSOR EMIL BEHNKE.

Brevooet House,
Fifth Avenue (near Washington Square),
New York, December 5, 188i
Messrs. Mariani & Co.,
19 E. 16th Street, New York,
Gentlemen : — Madame Valleria has desired me to state that she was greatly benefited by the using of your wine. Dr. Morell Mackenzie, of Harley Street, London, W., some years ago (three or four) recommended Madame Valleria in a similar instance to use your wine, and then, as now, she obtained instant and complete benefit from so doing, and, with compliments, I remain
Your obedient servant, R. H. PERCY HUTCHINSON.

Paris, December 2, 1880.
My Dear Sir: – Well ! yes; know it, and let me write it to you, though I have frequently told it you. Your Vin Mariani is indeed excellent, and equalled by nothing. I drink it, I absorb it, and so also does my family, and we are all deriving so much good from it that I shall never be without it. On my voice it acts like a charm. My friends and brother artists, to whom I have recommended it, drink it regularly and likewise speak in highest terms of the Vin Mariani, and I can only say I advise all artists to give it an experiment, and guarantee they will adopt its use and thank you for it, as I do with all my heart .
MELCHISSÉDEC,
Of the Opera.

Dear M. Mariani : Paris, November 12, 1881.

“Your wine indeed has again saved me! Upon my arrival at the opera and just before the commencement, when I was to sing, I found I had got a severe attack of aphonia, which has disappeared as if by enchantment after I had taken slowly a glassful of your wonderful Vin Mariani. It is to be hoped that all singers will become aware of and utilize the excellent properties of your preparation.

I have tried everything, and never have found anything like it. If the government understood all its duties, it would provide a certain quantity daily for the use of our corps of lyric artists— at all events for all the pupils pf the Conservatory of Music.
Gratefully, I am yours, VICTOR CAPOUL,
Of the Opera,

Fifth Avenue Hotel
Deae Doctor : August 24, 1884
We wish to pay a tribute to the excellence of the Mariani Wine. We invariably use it during our professional labors, and find it very efficient as a tonic which strengthens the vocal organs. We never travel without it, and thank you very much for recommending us to use it. Yours, etc.,
MR. & MRS. W. J. FLORENCE.

No. 21 Fifth Avenue,
New York, December 10, 1883.
Dear Sir: – I have had occasion to speak with many of my brother-artists of the Vin Mariani. Yesterday 1 was suffering with a lowering of the voice and determined to take this wine. Well, I can assure you that it gave me im- mediate relief, and that I shall always make use of this Vin Mariani on all occasions that I have any trouble with my voice. If 1 had a singing school, I should give to my pupils, as a specific for strengthening the vocal cords, this Mariani Wine. Accept my most sincere congratulations, and believe me,
Yours faithfully, GIUSEPPE DEL PUENTE.

220 W. 38th Steeet
March 20th, 1884.
My Dear Sir: – I desire to testify to the excellent effects of the Vin Mariani. Having been for months troubled with nervous prostration, I was delighted to find the wine a most strengthening tonic. It was prescribed for me by my physician. Recommending it heartily to all who all called upon to endure the fatigues of public life, I am, dear sir,
Very sincerely yours, HENRIETTA BEEBE.

New York, July 16, 1884.
Deae Sir :— I have often wished to express to you the wonderful results produced upon my voice by the use of the Vin Mariani, prescribed by my physician eighteen months ago. During my sojourn South I had occasion to use it many times, with marvellous results; when my voice was exhausted from excessive use and so hoarse that not one word out of ten was understood, I would take a sherry glass full of the Vin Mariani and captivate my audience by my full and brilliant voice, really astonishing myself thereby. It certainly is invaluable to vocalists and elocutionists— soothing irritation of the throat, and giving strength and brilliancy to the voice. Feeling deeply grateful, I am,
Most respectfully yours, MARG. BOULIGNY.

Messrs. Maeiani & Co., New York, December 16, 1883.
Gentlemen : — I have used your wine during several years, and have found it excellent. I am well satisfied with it, and cheerfully authorize you to use my name.
Very respectfully, E. FURSCH MADI.

Mariani & Co., Mystic Bridge, Ct., August 12, 1884.
Deae Sirs :— I have taken your Wine of Coca since July 24th, as directed by my physician. I am pleased to write you that I have been greatly benefited by it. My lungs are better, and my general health is in every way improving. I can safely recommend it to my friends as the best tonic I have ever taken. My home physician is so much pleased with the effect of the wine upon me that he has already sent to you for a dozen bottles.
Respectfully yours, FANNIE S. WILLIAMS.

St. James’ Hotel
Mariani & Co., N. Y. City, February 25, 1884.
19 East 16th Street, N. Y. City,
Gentlemen: – For several years I have been using various preparations of Coca, and within the last few months, having had my attention called to your Vin Tonique Mariani, have been using it. I think it by far superior to any that I have yet seen, and I have derived great benefit from its use. Judging it from my own experience, I can and do most heartily recommend it.
Yours, etc., EMORY A. STORRS,
Chicago.

Continental Hotel
Mariani & Co., N. Y., August 25, 1884.
Gentlemen: — It affords me great satisfaction to give you the result of my personal experience in the use of Vin Mariani. For the past three years I have, under the direction of my physician, relied upon it in serious emergencies of illness and overwork. It sustains vitality in conditions of extreme exhaustion, and restores strength more quickly than any other tonic I have used, never causing the least unpleasant reaction.

I have tested it during long journeys, under the pressure of continued physical and mental strain, and have found it unfailing in its good effects. Frequently, when in travelling I have been unable to obtain my regular food, a small quantity of Vin Mariani has afforded me satisfactory nourishment.

I am so convinced of its beneficial nature, that I have induced many of my friends to use it, and their experience coincides with mine.
Respectfully yours, JULIET CORSON.

(The following is from the eminent Professor J. M. Carnochan, M.D., of New York, Professor of Surgery, former Surgeon-in-Chief to the State Emigrants’ Hospital, Health Officer of the Port of New York, and one of the Commissioners of the Health Department of the City of New York, etc.)

M. Mariani, Paris : New Yoek, August 29, 1884.
I have for the last eight or ten years often recommended the Vin Mariani to patients laboring under abnormal conditions of the system, re- quiring a mild tonic and stimulating influence, with marked and excellent results. For convalescents, also, I consider it a very useful remedial agent.
J. M. CARNOCHAN, M.D.

Mr.. A. Mariani, Paris, October 19, 1880.
Dear Sir : — As a rule I object to having my name used as recommending any special preparation of a drug, for this very easily and frequently leads to abuse; but I am willing to make an exception in your case, and to express at your desire, in writing, my opinion of your Wine of Coca – an opinion with which you are personally well acquainted. Since my attention has been called to the good effects of your wine by Drs. Morell Mackenzie and Lennox Browne, of London, I have tried it myself, and have observed its use by Dr. Fauvel, in his clinique and in his private practice. There can be no doubt that, properly used, it is an excellent general tonic; that it has a special beneficial action upon the digestive and respiratory organs, and that, by its stimulation of the nervo-muscular system, it enables persons to undergo physical exertions to which, without it, they would at the time not be equal, and seemingly – certainly so far as I have been able to discover – without consequent reaction of over-fatigue. The latter effect I have particularly observed, as to vocal efforts, in the cases of speakers and singers.
DR. LOUIS ELSBERG, Of New York.

19 Harley Street, Cavendish Square, W.
London, July 6th, 1885
Gentlemen: – I have much pleasure in stating that I have used the Vin Mariani for many years, and consider it a valuable stimulant, particularly serviceable in the case of vocalists.
Yours faithfully,
MORELL MACKENZIE, M.D., London,
Consulting Physician to the Hospital for Diseases of the Throat; late Physician to the London Hospital.

Wiener K. K. Allgem. Krankenhaus
Vienna, July 20th, 1885. f
Messrs. Mariani & Co.
Dear Sirs : — I have used your Vin Mariani for the past three years, and have much pleasure in testifying to its many excellent qualities, combining as it does the well known constitutional effects of Cocaine with that of a mild stimulant exhibited in an acceptable form. Among the conditions in which I have found it of valuable service, I may mention in the debility occurring after prolonged illness – in Oedema of the Larynx accompanying albuminuria, in the slow convalescence after diphtheria, and especially in Graves’ disease, in which latter it not only acts as a cardiac sedative, but also diminishes the accompanying exophthalmos and laryngeal congestion.
I have the honor to be, Yours respectfully,
GEORGE W. MAJOR, B.A., M.D.,

Montreal, Canada.
Professor in Laryngology, McGill University, and Laryngologist and Rhinologist to Montreal General Hospital.
Saratoga Springs, July 20, 1885.
Gentlemen : — I have used the Vin Mariani in my practice quite largely for the last four years with most excellent results, and I consider it greatly superior to any other preparation in the market.
Very truly yours, CLINTON WAGNER, M.D.,

341 5th Avenue, New York.
New York, August 28th, 1883.
Gentlemen : — I have been acquainted with Mariani Wine for a considerable time, and have had occasion to recommend it frequently. I deem it a most excellent adjuvant in the class of cases to which it is recommended, and I hope in the future to still further demonstrate its usefulness.
Very respectfully,
WALTER R. GILLETTE, M.D.,
149 W. 23rd Street.

Utica, New York, July 17th, 1885.
My Dear Sirs : — I have used the Vin Mariani in many cases, and have had considerable experience with it. In my opinion it is the best preparation of Coca attainable, and can be relied upon in many conditions of debility and feeble heart action when this valuable drug is called for.
Very sincerely yours,
EDWIN HUTCHINSON, M.D.

Boston, December 15, 1884.
Messrs. Mariani & Co.: – Enclosed please find amount for two cases Vin Mariani, which please send by Adams’ Express. I use it in my own family. I have been more than pleased with its action, and consider it far ahead of any other preparation of coca, be they wines, fluid extracts, or elixirs. I have tried in my practice no less than six different preparations.
Yours very truly,
CHARLES G. BROOKS, M.D.

Hudson, New York.
Gentlemen : — Your Vin Mariani is giving excellent results. I am well pleased with its effects.
Yours truly,
C. P. COOK, M.D., Health Officer.

New York, June 24th, 1885.
Dear Sirs: — Permit me to say that I am, and have been for years past, using your preparations of Coca, and that I fully endorse all the views that I formerly expressed about them. They are the only preparations of Coca from which I can obtain any medicinal results, and necessarily I use them exclusively, and consider your wine superior to any other makes. Many thanks are due you for your excellent preparations, and I trust others will obtain as good results from them.
Very respectfully yours,
WILLIAM H. MORSE, M.D.,

153 East 77th Street.
Vicksburg, Miss.
Gentlemen : — The “Thé Mariani” is certainly a surprising invigorator. 1 am using it with great satisfaction in debilitated subjects. Were the several fluid extracts and preparations of Coca now on the market of better grade, Coca would hold the place it deserves. Yours is the only preparation I use with confidence. Very respectfully,
H. P. BRISBANE, M.D., Health Ofiicer.

Boston, Mass., October 3rd, 1885.
Dear Sirs: – My first acquaintance with the use of Vin Mariani was made in Paris, France, in the summer of 1880, when my attention was called to it by Dr. J, Marion Sims, who recommended it as a superior tonic for nervous prostration. I have continued to use it and prescribe it ever since with entire satisfaction. I prescribe your Elixir Mariani as a brain food, and as a stimulant to the nervo-muscular system it gives immediate and lasting effect. I also have used your “Thé Mariani” in sweetened milk, and think it excel- lent. I am so convinced of the beneficial effect of these preparations that I hardly know how I could practice without them in such cases.
I am, respectfully yours,
A. W. K. NEWTON, M.D.

Brooklyn, New York, June 23rd, 1885.
Gentlemen: – As regards your preparations of Coca, it gives me pleasure to say that at the present time I can obtain none which is so satisfactory as your Vin Mariani and your Thé. I have always found same uniformly excellent and reliable. My opinion of the value of Coca in general is so well known that I need not express it.
Respectfully yours,
W. S. SEARLE, M.D.
Health Department, Sanitary Bureau,

New York, October 3rd, 1885.
Mariani & Co.
Gentlemen: – I have frequently prescribed your Vin Mariani, and am familiar with its merits. I have, however, never seen any of your other preparations of Coca, and would be indebted to you for samples you so kindly offered. If they are up to the standard of your wine, you deserve to reap great rewards for devising and introducing them.
Very truly yours,
CYRUS EDSON, M.D.

New York, September 14th, 1883.
Dear Sirs: – I have used your Vin Mariani with decided benefits. Of the many preparations of Coca I find the Mariani wine the best, and I have tried many of the others. It produces an immediate tonic effect, and the improvement is lasting. I have ordered it for many of my patients, and it has not disappointed me.
Very truly yours,
S. A. FOSTER, M.D.

Augusta, Ga., January 13th, 1885.
Gentlemen: — I have been prescribing your Vin Mariaiii for some time, and with entire satisfaction. I am just recovering from an attack of diphtheria, which 1 contracted from a patient, and on account of my extreme debility I took your wine and have finished the fourth bottle, and can say I am a new creature since I commenced it, and certainly shall continue taking it for some time. Without doubt it is the greatest tonic ever made, and I am prescribing it every day.
Very truly yours.
E. C. GOODRICH, M.D.

Yonkers, New York, May 6, 1884.
Dear Sirs : — When in Paris I heard of the Vin Mariani, and the good results from using the same, particularly in the treatment of certain obscure nervous diseases. Since my return home I have advised in quite a number of these nervous cases the taking of the Vin Mariani, and with most favorable results. Am pleased to say that the Vin Mariani continues its reputation, and is growing in favor.
Yours respectfully,
GEO. B. UPHAM, M.D.

Amherst, N. H., November 12th, 1884.
Gentlemen: – I had occasion many times to use the Vin Mariani in my practice, and found it the most elegant and efficacious preparation of Coca. It entirely covers and conceals the rather disagreeable taste of the drug, and in my estimation the wine itself is a most happy adjunct to the Coca, in that the alcohol therein contained quickens the absorption of it into the circulation, and, with the essential ether of the wine, adds to the strength-giving properties of the Coca. I consider that the Vin Mariani has saved my wife from sickness, which would have resulted from the breaking down of her nervous system. I have every reason to congratulate myself on the marked effect which the Vin Mariani has upon her. I am glad to recommend it as a superior preparation.
Yours, etc.,
HERBERT D. HICKS, M.D.

From Columbus Medical Journal:
“Cocaine in Headache.”
We received several months ago a supply of the justly celebrated Vin Mariani, with the request that we use it personally for the relief of headache – which is the bane of our life. This wine has for its active ingredient a concentrated extract of the leaves of Erythroxylon Coca – the plant from which the new anӕsthetic is obtained. Each wine-glassful contains the equivalent of about 30 grains of the leaves. Although we have used the Vin only when we felt the attack coming on, it has uniformly aborted the attack promptly and thoroughly. We have used it with others, and with essentially the same success. We have also prescribed it as a tonic in dyspepsia and nervous prostration, and with excellent results.”— J. F. Baldwin, M.D., Editor.