panaceachronicles

Pure, Natural Coca Leaf – A Healing Gift Of The Divine Plant


Leave a comment

Burqas Poison Muslim Women & Their Babies With Toxic Gas

Studies show that 90% of Saudis over age 60 have osteoporosis due to Vitamin D deficiency, in spite of living in one of the world’s sunniest regions. This means that virtually all Saudi women over 60, and most of the men, have this crippling bone disease simply because their body doesn’t get enough sun to make the Vitamin D they need for maintaining natural good health. The reason is simple – women are covered head to toe to protect men from “lustful thoughts”, which of course, also blocks the sun and prevents natural Vitamin D formation. It’s ironic that the same thing happens to many Saudi men – though not, of course, to the elite who only “cover up” when its time for a photo opportunity and otherwise wear Western clothes.

Severe Vitamin D deficiency is not a minor issue, and its effects are not limited to osteoporosis. It is a widespread, very dangerous condition that gives rise to all kinds of crippling, often lethal diseases and conditions. It causes, at any age, impaired immune system function, insulin resistance & diabetes, cancer, multiple sclerosis, hypertension, stroke, heart disease, infant mortality, chronic pain, anxiety and depression, and infertility. The fact that the full-body covering for women demanded by conservative Islam is responsible for the worldwide Vitamin D deficiency in Muslim women is indisputable. See here, and here – just two of many examples.

So, the role of mandatory Islamic dress for women in causing Vitamin D deficiency is well-established. But that is not the topic of this post.

I want you to know that there is another equally insidious, perhaps even more severe health issue caused by the medieval Islamic dress codes for women that has never been discussed in any research that I can find.

Without making any comment on the cultural, religious or moral issues raised by those who oppose women being forced to wear the Burqa by Islamic law, there is another severe health threat created just by those little black full-face masks they are forced to wear.

Quite plainly, being forced to wear a Burqa exposes Muslim women throughout their lives to highly toxic, potentially crippling and even lethal poison gas.

The mechanism by which this happens should be obvious, even though as I said it has never been studied. Wearing the Burqa traps CO2-laden exhaled breath so that it is continually re-inhaled. The Burqa-wearing woman is never breathing fresh air – she is always re-breathing her own exhaled gasses. This increases the level of CO2 and lowers the O2 levels in a woman’s blood all day, every day, to the point that it endangers her health, quality of life, and longevity, and almost certainly to the point of adversely affecting health of her children.

While the mechanism by which Burqas poison their wearers is obvious, as just pointed out there is not a single piece of medical and scientific research that examines the impact of wearing the Burqa on blood CO2 and O2 levels. Do you find that as odd as I do? Has this research topic simply been overlooked? Or has it been suppressed?

Fortunately, there actually is research on the impact of wearing surgical masks on the blood CO2 and O2 levels of surgeons, and the conclusions are quite straightforward – although, oddly enough, this is also not a well-researched area.

What the available research shows is that wearing surgical masks for an extended period day after day, as surgeons do, significantly increases their blood CO2 and decreases their blood O2 levels. 

Here is a brief quote from one of the few papers I was able to find on the topic.

Ergonomics. 2013;56(5):781-90. doi: 10.1080/00140139.2013.777128. Epub 2013 Mar 21.

“Carbon dioxide rebreathing in respiratory protective devices: influence of speech and work rate in full-face masks.”

Smith CL, Whitelaw JL, Davies B.

“Carbon dioxide (CO2) rebreathing has been recognized as a concern regarding respirator use and is related to symptoms of discomfort, fatigue, dizziness, headache, muscular weakness and drowsiness.”

Well, that doesn’t sound too bad, does it – unless you are being operated on by a dizzy, weak, fatigued and drowsy surgeon.

But let’s dig a little deeper into the health consequences of prolonged exposure to CO2 at levels above what we would encounter breathing normally, with nothing covering our mouth and nose.

This US Department of Energy study is a bit more informative.

The following table summarizes the results of chronic CO2 exposure at low levels, but in excess of what would be inhaled under normal conditions. It is a reasonable assumption that these consequences are also incurred by women wearing Burqas, particularly since, as you will notice, the length of exposure in the various studies were only a matter of days or weeks of exposure, whereas women wear Burqas for large portions of the day throughout their lifetimes.

After giving us this table, that summarizes over a dozen research studies, the DOE goes on to explain the health consequences of CO2 exposure noted in the studies.

Lung dead space volume is a volume of air where gas exchange does not occur. The larger the dead space, the less gas exchange, which can be important for those with pulmonary or cardiac problems. Patients with severe CO2 retention (PaCO2 >95 mmHg) are invariably acidotic and will be at greater risk for profound acidosis with elevated ambient CO2 concentrations because they cannot further compensate for elevations in PaCO2, except with limited increases in ventilation. In addition, although the CO2–induced increase in the dead space volume was reported to be reversible in healthy subjects, it is not known if this reversal also occurs in patients with pulmonary disease.”

“Elevated systemic and pulmonary blood pressure is well tolerated by healthy individuals but can exacerbate preexisting systemic or pulmonary hypertension. Increased cerebral blood flow and increased intracranial pressure can put preterm infants at increased risk for intraventricular hemorrhage. Adults with brain injuries, tumors, bleeding, or increased intracranial pressure are also at risk with further increases in intracranial pressure.”

“Slightly decreased bone formation and increased bone resorption in healthy young individuals may have no long-term consequences but may be detrimental to persons with bone disease, such as osteoporosis. Another potential problem is increased blood calcium, which is related to changes in the bone. In guinea pigs and rats, focal renal calcification has been observed with prolonged exposure to concentrations of CO2 ranging from 0.3 to 15% [42-48]. The authors characterized the kidney calcification as an adaptive disease. Studies of humans have not examined calcification in the kidney or other organs.”

Bottom line – neither science nor medicine has paid much attention to the health consequences of daily exposure of health care workers to even slightly increased level of CO2, much less to the life-threatening health issues experienced by millions of Muslim women forced to wear Burqas or be publicly flogged.

If Muslim women are being deprived of Vitamin D and are being chronically poisoned by CO2 as a direct result of how they are forced to dress by the male-dominated religious societies into which they are unfortunate enough to have been born, isn’t this as horrific a crime against humanity as female genital mutilation, another travesty imposed on women by these same male “religious” criminals?

Of course it is. The question is – when is the non-Muslim world going to recognize that an enormous criminal conspiracy, inspired by hatred and fear of women, exists in many if not all Muslim countries, and when are the Muslim leaders of these misogynistic gangs masquerading as religious organizations going to be indicted by the World Court for the genocide they are surely committing? 

Ban the Burqa. Indeed!


Leave a comment

Is A Simple Nutritional Supplement Poisoning You?

Are you or someone you care about suffering from muscle pain, abdominal pain, neurological symptoms including numbness and blurred vision, nausea, fatigue, gut irritability, severe digestive problems, and symptoms of an impaired immune system including severe reactions to some foods? Are you unable to find a diagnosis that will enable treatment? Have you tried everything?

My wife had all of these symptoms to the point that she could barely get out of bed most days and would cry from the continual pain and despair. She became afraid of eating because almost everything hurt. We tested for literally everything. We did find that she has Hashimoto’s Thyroiditis, but now has it under control. But that was it – nothing else was found after literally dozens of kinds of tests. We actually had to wrestle with doctors to get some of those tests ordered – including the one that found Hashimoto’s, which that doc tried to shame us out of demanding.

Life was getting to the point where we were seriously talking about the “Thelma & Louise” solution. She couldn’t face living this way and I couldn’t face living without her.

I know that many people are going through something similar, and haven’t been able to find a doctor who could help. As you probably know, most docs don’t like to see patients who they can’t “cure” with a prescription. Anything else and you are put into the “difficult patient” category and they start working hard to convince you that you are causing your own problem. Women especially find male doctors suggesting that their problem is what used to be called “hysteria”. Most doctors where we live simply didn’t believe her and told her so, and it got to the point where she stopped trying to get medical help from such idiots.

We are both reasonably intelligent people and we have spent literally years reading everything that might offer a clue. We are careful what we read, and most of what we pay attention to is on the fantastic NIH database PubMed, which has ONLY peer-reviewed medical journal articles. There are so many diseases and conditions with some or all of her symptoms, but no definitive answers emerged.

My wife has always taken nutritional supplements including probiotics. She is very careful about the quality of what she takes, and we learned long ago to check what is actually in the supplement in addition to its “main” ingredient. For example, it is very hard to find Vitamin C that doesn’t include “citrus bioflavonoids”, and she reacts violently to all forms of citrus, pineapple, cherry, etc., so we have always been careful.

I’m getting to something that may be important for you to know, but had to give you some background.

Here it is.

Several years ago one of her doctors, a really brilliant female naturopath with a full MD and a background as an ER physician, recommended that she begin taking a Zinc supplement. Specifically she recommended Zinc Picolinate, because it is a form of Zinc that is “more easily absorbed”.

So after looking around we settled on a Bluebonnet brand 50mg Zinc Picolinate supplement, once daily with a meal. It became part of her everyday program, and we never questioned its value.

Then for some reason – perhaps a guardian angel whispering in our ear – two weeks ago we decided to look into Zinc toxicity, and up popped a bunch of citations, but the Mayo Clinic’s comments were a revelation. According to Mayo, the UPPER LEVEL of daily intake of Zinc for an average adult is 40mg. That’s zinc from ALL sources, not just a pill. Even 40 mg/day is WAY excessive for most people, but going over that can lead to exactly the list of symptoms that my wife has been experiencing, all getting progressively worse over time because Zinc toxicity is cumulative. There it was – she was POISONING HERSELF WITH ZINC.

And how do we know that? She stopped taking the Zinc supplement and within two days ALL of her symptoms began to decrease. It has been almost two weeks and almost every symptom is GONE. She has energy, her muscles don’t hurt, she can eat without pain, she can be active without crashing and burning, her brain fog is gone, and her spirit is strong again. She can even eat a little popcorn. With butter! (Goat butter – she’s not ready to risk cow dairy yet.)

We are even hopeful that once the toxicity that has been building up for years is gone (it can be gradually excreted, although some damage may be permanent – we don’t yet know), perhaps she will be able to enjoy a more varied diet, even – please God – the occasional pasta dinner and maybe even an egg and piece of toast with butter for breakfast. It’s probably too much to wish that she could also enjoy a glass of OJ, but who knows?

If you, or that person you care for, are taking a Zinc supplement in the “standard” 50 mg dose, you are exceeding the UPPER LIMIT according to the Mayo Clinic and you might want to consider leaving it out of your diet for a week and just see what happens. It appears that this has been the problem all along for my wife. This is surely not the only health issue she faces, nor the answer to everything, but it seems that we have just received a miracle.

Perhaps this simple solution will help you. It appears to have worked for us. Good luck to us all. God bless.


Leave a comment

Inflammatory Comments About Sick Guts

As a long-time advocate for the medical applications of Cannabis as a natural medicine I’ve noticed that a rather overwhelming number of people these days who suffer from so-called gastro-intestinal ‘diseases’. I say so-called not because I am an expert, or a doctor, or a scientist, but because the person I love most in the world has been on a very long and painful ten-year journey during which she has been continually failed by every expert, scientist and doctor we have asked for help – although there have been a few who sincerely tried to be helpful.

During this journey we have had to basically help ourselves because as I’m sure you know if you have a medical problem that can’t be easily ‘cured’ most doctors quickly lose patience with you and can’t wait for you to disappear and stop ruining their self-image as infallible healers. So for years my wife and I have spent hundreds of hours researching the literatures of medicine, science, nutrition, folk-medicine, healing arts, and anywhere else we could think of looking, trying to discover what makes sense and what doesn’t.

I would like to share some of what we believe are useful discoveries we’ve made that complement the almost magical properties of Cannabis and some of the other medicinal plants that we believe are gifts of the Great Spirit to the People of the world.

Your Tube

Your gut, as you know, is a long tube running from your mouth to your anus. It’s natural to think of your gut as being inside your body, but think about that for a minute and you’ll realize that whatever is inside your gut, that 36′ or so of tube, is actually outside your body. In a very real sense, the walls of your gut are the outside of your body very much like your skin, and whatever is inside your gut is not very different from whatever is on your skin – both are outside your body.

The reason this is important to visualize is that when your gut is compromised, what is inside your gut, much of which is naturally supposed to be kept outside your body, can move into your body in ways that nature did not intend. In other words, the purpose of your gut is to process your food and then allow ONLY the things your body needs to come through the wall of the gut and enter your body. These are mostly nutrients and water, and the rest of what is in your gut – the waste or non-useful materials that are supposed to be excreted – are meant by nature to be kept OUT of your body.

Just like when your skin is broken and you get an infection because foreign materials (and bugs) have moved into your body through the broken barrier of the skin, and your body rallies its defenses, led by inflammation, its #1 defense, when your gut is compromised materials (and bugs) that are supposed to be kept outside can move into your body where they trigger the body’s immune system defenses.

The skin and the walls of the gut are obviously both somewhat permeable. In other words, you can absorb certain kinds of things through your skin, but your gut tissues are designed to be much more absorptive. One big difference between your skin and your gut is that the tissues of the gut are very specialized and are designed to allow nutrients from your food through so that you can be nourished. And that is where the beginnings of so many of our GI ‘diseases’ occur. When the gut tissues are compromised, and the barriers that have previously only allowed fully digested nutrients to move through the gut wall now allow other materials, like undigested proteins, to move through the wall, the body’s immune system is triggered and all kinds of hell break loose.

Good Bugs/Bad Bugs

One of the realities of our gut is that it is absolutely chock full of bugs. All kinds of bacteria thrive in our gut, which as far as the bugs are concerned is divided into two sections – the upper gut and the lower gut. To oversimplify a little – not much – the good bugs live in your upper gut and the bad bugs live in your lower gut. The good bugs are all those species that are involved in keeping you healthy, helping you digest your food, creating hormones that help regulate your body’s functions, communicating back & forth with your brain, and importantly, keeping the bad bugs where they belong by colonizing the upper gut so completely that there is no place for the bad bugs to get a foothold even if they wanted to.

Now you take some antibiotics. It doesn’t really matter what kind – any anti-biotic will do. What happens? Well of course the anti-biotic is designed to kill bacteria and while some (very few) antibiotics kill only bad bugs like those causing an infection somewhere in your body, many antibiotics kill bugs rather indiscriminately. One of the realities of life is that it is harder to kill bad bugs than it is to kill good bugs, so anytime that strong systemic antibiotics are used there is a big die-off of the good bugs in the upper gut, whereas the bad bugs in the lower gut hang in there.

But the story doesn’t end there, unfortunately. After the battle there is lots of open territory in your upper gut where colonies of good bugs used to live, and the bad bugs somehow know that this is the case (remember, these bugs communicate with each other) and they begin migrating upwards, staking out ground as they advance. And keep in mind that the bad bugs doing this are the ones who survived the antibiotics – only now they are resistant and much harder to kill.

One of the reasons that these are bad bugs, or pathogens, is that they don’t live in harmony with their host. When they are kept down in the lower gut, there are strong natural barriers to keep them from breaking down the tissues of the gut wall wherever they establish their colonies, but in the upper gut there are no such defenses and before long these colonies of bad bugs begin creating weak spots in the wall of the upper gut. They do this in various ways – by secreting acids that eat through the tissues, by killing off the specialized cells that regulate nutrient transport, and by slipping through the gut wall themselves to make a new home somewhere comfy like your heart or brain. Medicine even has a name for this situation – SIBO, or small intestine bacterial overgrowth. And the almost invariably prescribed ‘cure’ for SIBO? Well, you guessed it. More anti-biotics. If the phrase ‘vicious cycle’ is running through your mind at this point, you’re on target.

Many people already know about the importance of taking wide-spectrum Pro-Biotics to help restore the good bugs in your intestines after taking any kind of anti-biotic. Most doctors will not tell you this – they just prescribe or use these ‘medicines’ on you and then let you walk away to deal with the almost inevitable consequences. If I were a more cynical person I might suspect that they do this because it is good for business – they ‘cure’ or ‘protect’ you with anti-biotics and then because your gut has been compromised you are literally forced to come back to them because you now have all kinds of other problems that they can also charge you for ‘curing’. But that would be really cynical of me, wouldn’t it?

Please realize if you don’t already that it isn’t enough to just eat yogurt containing acidophilus bacteria – in nature there are thousands – maybe millions – of different kinds of bacteria and other micro-organisms that live in your gut, and just like in a forest or meadow diversity is the key to ecosystem health, so too in your gut. There are many different brands of wide-spectrum Pro-Biotics, and you don’t have to spend a fortune to get a good one. My advice – for what its worth – is to look for a brand that has at least 3-4 billion bacteria per dose and has at least 6 different species of bacteria.

The Problem With ‘Medicines’

If you are one of millions of people who have been diagnosed with gastrointestinal disease you already know that none of the expensive, often toxic ‘medicines’ and ‘treatments’ actually help much although, as my wife and I can testify, the ‘system’ is set up to keep draining you financially until there is nothing left at which point you are cast aside, with your life ruined and your health unimproved. Medical marijuana advocates also know that not only medical marijuana but other inexpensive natural medicines can help tremendously, and although there is still no cure for these diseases, Cannabis offers a better more natural way of managing the symptoms than what any of the conventional treatments and “medicines” have to offer.

Before I get into some of the things that my wife and have found actually can make a huge difference in your health if you are living with a compromised gut, let me first bring up what we have learned about an undiagnosed problem directly related to a compromised gut that actually can be very effectively diagnosed and managed, and that affects at least 10-15 million people in North America alone without most of them knowing they are slowly being literally eaten alive.

It all begins with your body’s immune system. I don’t pretend to understand this complex system of defenses, but I do know one important thing, and that is that the immune system can sometimes go a little crazy and start doing things it was never supposed to do – like attacking the body itself rather than attacking outside threats to the body that have somehow entered or invaded the body. This is called an auto-immune response, headed by inflammation, and is I believe at the root of a huge undiagnosed problem that I hope anyone who suffers from any kind of gut issues will think about carefully.

Many if not most people who suffer from intestinal diseases also have been diagnosed, or just simply know from their own experience, that they are either sensitive to or intolerant of gluten. Briefly gluten is a naturally occurring protein found concentrated in wheat and related grass seeds – what we call grains in our diet. Without going into detail, which is readily available elsewhere, modern wheat bears little if any resemblance to its natural ancestors. The two biggest ways that modern wheat varies is that it is extremely high on the glycemic index, and it is extremely high in gluten.

But this post isn’t about gluten, so let me move to the key point I want you to know. When the body is gluten-sensitive or intolerant this can only occur because the gluten is moving from inside your gut through the wall of the gut as an undigested protein, and the immune system which is always on high alert for foreign proteins (like foreign bacteria) sees it and attacks. The results are so unpleasant that many people try, and some succeed, in switching to a gluten-free diet. But here is the important point. What these folks, and those who don’t stop eating gluten, don’t realize is that the gluten protein molecule is a precise double for a protein found in the human thyroid, and once the immune system has been triggered to attack a gluten molecule that has migrated through the intestinal wall it is forever on the outlook for precisely that protein. Whenever it detects that protein it will attack and destroy it.

Which means (I know you’re ahead of me here) that once your immune system is trained to attack gluten it will start attacking your thyroid too and will not stop until your thyroid is destroyed. There is a name for this process and it is Hashimoto’s Thyroiditis, and it is estimated that 10-15 million people in North America have it and don’t know it and so, of course, are not treating it. The really strange part of this is that while your immune system is attacking and destroying your thyroid, the most common tests for thyroid function that doctors order – the T3 and T4 tests – will almost always show that your thyroid is normal. Unless your doctor orders two tests for thyroid antibodies there is no way to know whether or not your thyroid is being destroyed by your body’s immune system. Be prepared for your doc to say “You don’t need that test – your Thyroid levels are normal.” I would guess that well over 90% of the docs in America would say just that. Maybe they aren’t idiots, but they are incredibly irresponsible to take that position. Of course it is all driven by insurance companies who are forever pressuring doctors who order “unnecessary” tests. In the case of Thyroid antibody tests, which even if you pay 100% of the cost yourself will run about $60, there is simply no excuse for not ruling out – or in – Hashimoto’s Thyroiditis.

But once you have these simple, inexpensive tests, if they reveal that you do have Hashimoto’s, a small miracle will come your way. Once you begin hormone replacement therapy, which is as simple as a very small dose of thyroid hormone every day, you will be amazed at how much better you begin to feel almost immediately. Many of your gastrointestinal symptoms will in fact begin to diminish and disappear. If you have been going through these painful, unpleasant, debilitating symptoms for many years, and many people have, it will seem almost too good to be true. And while it is not too god to be true, it is still not enough – there is more that you must do. But at least you will now be getting significant relief.

The Role of Diet

I’ve already promised that I won’t try to propose some universal cure for GI “diseases” like IBS, colitis and Crohns. For many readers it is enough that medicinal marijuana provides daily relief, and some may not want to go to the trouble of going further in self-treatment, especially through making dietary changes that can be difficult. But for those who are motivated I would like to make a few recommendations for things you might try. No promises, but these methods have worked for my wife and for others.

We’ve already discussed the role of gluten in triggering your body’s immune system, but for people with a compromised gut, whether from bacterial overgrowth due to misuse of antibiotics or for whatever reason, it is very important to ensure that no proteins can make it through your gut walls into your bloodstream because while the immune system is on guard for many different kinds of things, foreign life forms (except viruses, which may or may not be a life form) are always protein-based, and so any proteins – not just gluten – that get through the gut wall barrier trigger a massive immune response led by whole-body inflammation. This inflammation isn’t easy to understand or diagnose – it can mask itself as weight gain or as a wide range of other symptoms which appear to have no specific origin. Also whole-body inflammation isn’t like an infected finger or toe – it isn’t localized and therefore doesn’t stand out from the surrounding tissue. It is everywhere, and it is so subtle that most of us never spot it the way we would an infected finger.

Fortunately there is a relatively simple change that you can make that will reduce the migration of proteins through the gut wall and therefore greatly reduce the inflammation that always accompanies immune system’s inflammatory auto-immune response and that, in turn, lies at the heart of so much of what we call disease – especially disease that appears to Western medicine to have no specific cause. If it isn’t a bug or virus causing the disease, or an injury, or a cancer, or degeneration of an organ – then Western medicine is pretty much stumped. While many doctors are beginning to appreciate the role of inflammation in these diseases without an obvious origin, allopathic (Western) medicine still has very few effective tools for dealing with inflammation, which means that you are pretty much on your own.

But, here’s what you can do. It is called partitioning your diet, and the principles are simple. You divide your meals into two parts. Part one is the protein, and Part two is everything else. Since undigested proteins are one of the major triggers of immune system’s auto-immune response leading to inflammation, divide your meals into a protein part which you eat first, and then wait 30 minutes for your stomach acid to break it all down into the smallest possible components that can then be processed by the enzymes in your upper gut so that no undigested protein remains to penetrate the compromised wall of your upper gut. It takes about 30 minutes for the protein component of your meal to be broken down. Since so many ‘treatments’ of GI problems involve taking ‘medicines’ like Omeprazole that act to reduce stomach acid, if you are taking any of these drugs you may need to look into natural digestive aids like enzymes to help you break this protein down once it makes it into your upper gut. It is important not to drink liquids during the time your protein meal is in your stomach – this dilutes the stomach acid and defeats the goal of complete breakdown of the proteins.

Once you’re confident that your stomach has emptied go ahead and enjoy the your veggies and, if you can tolerate them, maybe non-gluten grains like rice and quinoa – although some people simply have to get all grains out of their diet. If you have had a compromised gut for a while you may also have developed multiple food allergies. Some of these can seem very strange. My wife, for example, reacts very strongly to all citrus, to pineapple, dairy and simple carbs like potatoes. She has decided that she just has to adjust to life without these things in her diet and is strong-willed enough to stick to her decision. I know that there are times she would kill for a bag of potato chips or a pizza with triple cheese, but she has made the decision that she would rather not be sick and so these things are gone forever. I hope that you, reading this, are not forced to such extremes but if you are I hope and pray that you will find the strength to treat yourself right and do whatever is necessary.

In honor of the central theme of the role of marijuana in self-treatment of a wide range of disease, let me offer three research citations that show that Marijuana plays its therapeutic role by reducing inflammatory responses – in other words, by regulating the immune system to reduce its auto-immune activities. These studies point to why so many people who are using Marijuana to treat their inflammatory diseases, whether of the bowel or elsewhere in the body, are having so much relief.

I’m writing this post to urge you not to stop there, but if you are not already taking some of the other steps covered here to treat the underlying cause of the inflammatory response rather than simply treating it with Marijuana, you might benefit greatly from doing so. The changes that you have to make to get further relief may or may not be drastic – everyone is different. But since you already know that there is at least one natural way to treat a medical problem that has the best minds in Allopathic medicine pretty much stumped, why not consider going even further and acting to remove some, if not all, of the major underlying causes of the problem that arise from what you eat and how you eat.

Three Studies

Israel Med Assoc J. 2011 Aug;13(8):455-8.

Treatment of Crohn’s disease with Cannabis: an observational study.

Naftali T, Lev LB, Yablecovitch D, Half E, Konikoff FM.

Source

Institute of Gastroenterology and Hepatology, Meir Medical Center, Kfar Saba affiliated with Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel. naftali@post.tau.ac.il

BACKGROUND:

The marijuana plant cannabis is known to have therapeutic effects, including improvement of inflammatory processes. However, no report of patients using cannabis for Crohn’s disease (CD) was ever published.

OBJECTIVES:

To describe the effects of cannabis use in patients suffering from CD.

METHODS:

In this retrospective observational study we examined disease activity, use of medication, need for surgery, and hospitalization before and after cannabis use in 30 patients (26 males) with CD. Disease activity was assessed by the Harvey Bradshaw index for Crohn’s disease.

RESULTS:

Of the 30 patients 21 improved significantly after treatment with cannabis. The average Harvey Bradshaw index improved from 14 +/- 6.7 to 7 +/- 4.7 (P < 0.001). The need for other medication was significantly reduced. Fifteen of the patients had 19 surgeries during an average period of 9 years before cannabis use, but only 2 required surgery during an average period of 3 years of cannabis use.

 

Journal of Molecular Medicine (Berlin). 2009 Nov; 87(11):1111-21. Epub 2009 Aug 20.

Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis.

Borrelli F, Aviello G, Romano B, Orlando P, Capasso R, Maiello F, Guadagno F, Petrosino S, Capasso F, Di Marzo V, Izzo AA.

Source

Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy.

Abstract

Inflammatory bowel disease affects millions of individuals; nevertheless, pharmacological treatment is disappointingly unsatisfactory. Cannabidiol, a safe and non-psychotropic ingredient of marijuana, exerts pharmacological effects (e.g., antioxidant) and mechanisms (e.g., inhibition of endocannabinoids enzymatic degradation) potentially beneficial for the inflamed gut. Thus, we investigated the effect of cannabidiol in a murine model of colitis. Colitis was induced in mice by intracolonic administration of dinitrobenzene sulfonic acid. Inflammation was assessed both macroscopically and histologically. In the inflamed colon, cyclooxygenase-2 and inducible nitric oxide synthase (iNOS) were evaluated by Western blot, interleukin-1beta and interleukin-10 by ELISA, and endocannabinoids by isotope dilution liquid chromatography-mass spectrometry. Human colon adenocarcinoma (Caco-2) cells were used to evaluate the effect of cannabidiol on oxidative stress. Cannabidiol reduced colon injury, inducible iNOS (but not cyclooxygenase-2) expression, and interleukin-1beta, interleukin-10, and endocannabinoid changes associated with 2,4,6-dinitrobenzene sulfonic acid administration. In Caco-2 cells, cannabidiol reduced reactive oxygen species production and lipid peroxidation. In conclusion, cannabidiol, a likely safe compound, prevents experimental colitis in mice

 

Arthritis Res Ther. 2008;10(2):R43. Epub 2008 Apr 16.

Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis.

Richardson D, Pearson RG, Kurian N, Latif ML, Garle MJ, Barrett DA, Kendall DA, Scammell BE, Reeve AJ, Chapman V.

Source

Centre for Analytical Bioscience, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK. denise.richardson@pfizer.com

Abstract

INTRODUCTION:

Cannabis-based medicines have a number of therapeutic indications, including anti-inflammatory and analgesic effects. The endocannabinoid receptor system, including the cannabinoid receptor 1 (CB1) and receptor 2 (CB2) and the endocannabinoids, are implicated in a wide range of physiological and pathophysiological processes. Pre-clinical and clinical studies have demonstrated that cannabis-based drugs have therapeutic potential in inflammatory diseases, including rheumatoid arthritis (RA) and multiple sclerosis. The aim of this study was to determine whether the key elements of the endocannabinoid signalling system, which produces immunosuppression and analgesia, are expressed in the synovia of patients with osteoarthritis (OA) or RA.

METHODS:

Thirty-two OA and 13 RA patients undergoing total knee arthroplasty were included in this study. Clinical staging was conducted from x-rays scored according to Kellgren-Lawrence and Larsen scales, and synovitis of synovial biopsies was graded. Endocannabinoid levels were quantified in synovial fluid by liquid chromatography-mass spectrometry. The expression of CB1 and CB2 protein and RNA in synovial biopsies was investigated. Functional activity of these receptors was determined with mitogen-activated protein kinase assays. To assess the impact of OA and RA on this receptor system, levels of endocannabinoids in the synovial fluid of patients and non-inflamed healthy volunteers were compared. The activity of fatty acid amide hydrolase (FAAH), the predominant catabolic endocannabinoid enzyme, was measured in synovium.

RESULTS:

CB1 and CB2 protein and RNA were present in the synovia of OA and RA patients. Cannabinoid receptor stimulation of fibroblast-like cells from OA and RA patients produced a time-dependent phosphorylation of extracellular signal-regulated kinase (ERK)-1 and ERK-2 which was significantly blocked by the CB1 antagonist SR141716A. The endocannabinoids anandamide (AEA) and 2-arachidonyl glycerol (2-AG) were identified in the synovial fluid of OA and RA patients. However, neither AEA nor 2-AG was detected in synovial fluid from normal volunteers. FAAH was active in the synovia of OA and RA patients and was sensitive to inhibition by URB597 (3′-(aminocarbonyl) [1,1′-biphenyl]-3-yl)-cyclohexylcarbamate).

CONCLUSION:

Our data predict that the cannabinoid receptor system present in the synovium may be an important therapeutic target for the treatment of pain and inflammation associated with OA and RA.