Cannabis, Tobacco, Inhaled Pesticides, Diabetes & Obesity – Connecting The Dots

Hello Friends – rather than asking futilely for foundation, institutional or god forbid, government support to fund this revolutionary little demonstration I’m putting it in front of the Cannabis community. My goal is to see the study done, whoever does it.

This simple little study will connect the dots above and demonstrate several new and compelling arguments for smoking and vaping only medical-grade and homegrown Cannabis and organic Tobacco.

It will also expose 50 years of government and corporate “War On Drugs” and “Anti-Tobacco” lies and propaganda for the organized criminal conspiracy they have been.

This harm reduction & health recovery self-management proposal for diabetic and obese Cannabis & Tobacco smokers is the practical, moral, & public health policy equivalent of giving clean needles to IV drug users and free condoms to at-risk sex workers.

Inhaled Pesticide Exposure and Diabetes

  1. Persistent Organic Pollutants and Type 2 Diabetes: A Critical Review of Review Articles
  2. Association between diabetes and pesticides: a case-control study among Thai farmers
  3. Exposure to pesticides and diabetes: A systematic review and meta-analysis
  4. Organochlorine Pesticide in Prediabetic & Newly Diagnosed Diabetes Mellitus Patients

Inhaled Pesticide Exposure and Obesity

  1. Potential contribution of insecticide exposure and development of obesity and type 2 diabetes
  2. Association between maternal exposure to the pesticide DDT and risk of obesity in middle age
  3. Association between Exposure to p,p′-DDT and Its Metabolite p,p′-DDE with Obesity
  4. Grandmaternal Perinatal Serum DDT in Relation to Granddaughter Early Menarche and Adult Obesity: Three Generations in the Child Health and Development Studies Cohort

The focus of this demonstration proposal is on one highly visible group of people who are affected by the trans-generational diabetic and obesogenic effects of inhaled pesticides – African American women. This is not to ignore the impact that inhaled pesticides from smoking pesticide-contaminated tobacco and cannabis are having on all other marginalized communities, or the diabetes, obesity and heart disease these contaminants are causing in smokers and their children in Latinx, Native American, Pacific Islander or the LGBTQ communities.

By focusing on this hidden chemical assault on generations of Black women and demonstrating its consequences I hope to raise awareness of the universality of the problem and to simultaneously to demonstrate a simple, straightforward non-clinical self-management solution for all diabetic and obese smokers.

SUMMARY

This harm-reduction intervention would significantly decrease African American women smokers’ EDC exposure risks by challenging commonly accepted assumptions about EDC exposure, diabetes, obesity, smoking, and health with a simple, transparent, non-clinical and culturally coherent community-based demonstration. If successful, this small study will open the door to new, practical, cost-effective, self-managed, sustainable harm-reduction strategies for diabetic African American women smokers, and potentially for other diabetic and obese women, men and children in equally affected marginalized communities.

DESCRIPTION OF PROPOSAL

This simple proposal addresses the long-running, perplexing, multi-faceted and seemingly intractable constellation of problems around smoking and diabetes that disproportionately affect African American women smokers. It will first demonstrate the effectiveness of a genuinely new approach to tobacco and cannabis harm reduction, self-management, and improved quitting outcomes, then work with compensated volunteer participants to test and demonstrate the model’s real-world viability and acceptability, then share the participants’ experiences across Social Media to raise awareness among African American women that self-management of their smoking behavior, diabetes, and possibly other health conditions including obesity and heart disease, is an achievable behavior change.

The proposed demonstration is designed to show that removing diabetic smokers’ chronic daily exposure to the pesticide residues that contaminate virtually 100% of the US cannabis and tobacco product supply will noticeably and measurably improve their diabetes symptoms and facilitate self-management of their disease.

This proposal challenges the universal assumption that the harm associated with smoking tobacco products is unavoidable because of the inherently dangerous nature of tobacco and nicotine themselves. We expect to demonstrate that regardless of whatever the other hazards may be, the impact of smoking and vaping tobacco and/or cannabis on diabetes is measurably reduced if pesticides are eliminated from the chronically inhaled smoke or vapor.

A powerful and novel aspect of the proposed approach is that diabetic smokers won’t have to quit smoking or vaping tobacco products or cannabis to test, demonstrate and validate for themselves and others that removing their chronic exposure to pesticides will, by itself, improve their health even when they do not stop smoking or vaping.

I believe this will offer a gateway to quitting altogether if desired, and to sustainable non-clinical self-management harm reduction options that did not previously exist.

THE SMOKER’S EDC EXPOSURE: ALL CLASSES OF PESTICIDES

“Pesticides … have been found to bind and alter the function of hormone receptors, alter the synthesis or clearance of endogenous hormones, interact with various neurotransmitter systems, and cause yet other effects by still poorly understood mechanisms. The pesticides which produce these effects on the endocrine system encompass a variety of pesticide chemical classes. Some of these pesticides are pervasive and widely dispersed in the environment. Some are persistent, can be transported long distances and others are rapidly degraded in the environment or the human body. However, even a brief exposure to pesticides which alter endocrine function can cause permanent effects if the exposure occurs during critical windows of reproductive development.” (emphasis added) US EPA “Pesticides as endocrine-disrupting chemicals” 2010

TOBACCO PRODUCTS & CANNABIS:

DUAL UNREGULATED SOURCES OF INHALED EDC EXPOSURE

“According to estimates from the Centers for Disease Control and Prevention, when considering race, rates of current tobacco use in African Americans (16.5%) surpass overall U.S. adult rates (15.5%). Trends in marijuana use among African Americans are also distinct and disconcerting. Specifically, marijuana use among African American adults is equal to or greater than use among Whites.

African American Women’s Tobacco and Marijuana Use: The Effects of Social Context and Substance Use Perceptions

THE HARD EVIDENCE

The following are unique data from privately commissioned testing and analysis conducted by an independent, qualified lab with extensive cannabis and tobacco pesticide residue analysis expertise. Young African American women, and their children, are at greater risk than any other demographic group due to exposure to clinically significant concentrations of particular inhaled EDCs from smoking specific tobacco products that target young African American men and women with high profile and heavily funded culture & entertainment marketing campaigns.

The compounds in red (first graphic) are unique to Swisher Sweets among the brands tested. Swisher Sweets is heavily marketed to young African American women and men.

Please note the globally banned EDC DDT in Swisher Sweets

Here you see a 2021 analysis of commercial cannabis samples from 23 US states.

(from) “Regulatory status of pesticide residues in cannabis: Implications to medical use in

neurological diseases”

The population-wide risk represented by EDCs being inhaled from contaminated tobacco products is substantially increased, perhaps more than doubled, by co-exposure through smoking black market cannabis contaminated with unregulated, unregistered and in some instances other banned pesticides like Paraquat that contaminate the unregulated, uninspected cannabis that predominates in Black communities. Tobacco-Cannabis cross exposure also occurs when smokers roll ‘blunts’ with black market cannabis using Swisher Sweets as wrappers, a popular African American community style.

NEW RESEARCH VALIDATES 2018 FINDINGS

This 2022 study is published by the Saudi equivalent of the US FDA The Saudi government, with this report, is the first public health authority since the mid-1970s to officially recognize the widespread contamination of cigarettes with medically significant levels of additive and combinatorial EDCs. The full original data is in the “summaries” section of the study.

Note that both Marlboro and Camels show heavy contamination in the Saudi 2022 samples as well as in the “Smoke No Evil” US samples four years earlier.

RELEVANT ASSOCIATIONS

We have a full bibliography of multiple peer-reviewed research literature citations supporting every point in this proposal. Selected links are included throughout.

The data above show that multiple EDCs are being inhaled simultaneously by smokers, each in medically significant concentrations, with additive and combinatorial effect, many times a day. This hard evidence shows that smoking cigarettes, little cigars and/or cannabis means inhaling a cocktail of EDCs that are by themselves, independent of the vegetative matter involved, individually and in combination, are strongly associated with or known to cause both adult-onset and childhood Type 2 diabetes. Solid published research shows that while dosage, co-exposure and duration of exposure mediate these effects, timing can be critical. In pregnant women who are smokers, since pesticides are designed to cross tissues like cell walls and the placental barrier, the developing child is exposed to these tobacco/cannabis EDCs at every stage of development daily, even hourly. The results of prenatal exposure to EDCs like DDT and other pesticides also include gestational diabetes in the mother, although this has not yet been associated with inhaled pesticides from smoking tobacco and cannabis.

1. Tobacco and Cannabis cigarette smoking rates are disproportionately high among young African American women and men and in other marginalized communities LINK
2. The prevalence of Type 2 diabetes and pre-diabetes at all ages is disproportionately high in African American and other marginalized communities LINK

> The rates of other diseases that are both smoking-related and pesticide exposure-related, including obesity and heart disease, are also disproportionately high LINK 

3. “Smoking causes diabetes” CDC LINK       

> Smoking cigarettes is strongly associated with obesity and heart disease. LINK

4. Any pesticide exposure increases lifetime risk for onset of Type 2 diabetes LINK 

> Also for obesity and heart disease LINK LINK

5. Fetal pesticide exposure is associated with childhood Type 2 diabetes LINK
> Also with midlife obesity in children and grandchildren of DDT exposed women LINK 

> Inhaled pesticides cross the placental barrier without First Pass intermediation LINK 

> The average cigarette smoker is exposed with 132 puffs/day LINK

6. Both Cannabis and Tobacco products are widely contaminated with regulated and unregulated pesticide residues at medically significant levels for chronic exposure. LINK

> Residue levels are regulated, with varying degrees of effectiveness in legal cannabis but not in black market cannabis LINK
> Controversially, smoking cannabis has been shown to reduce the risk of Type 2 diabetes, nevertheless the illegal pesticides shown to contaminate Black Market Cannabis are known to be potent additive and combinatorial EDCs LINK

> Despite the deceptive appearance given by Section 907, pesticide residue levels are effectively unregulated and unreported in tobacco products LINK
7. Extensive cross-exposure occurs because 80% of cigarette smokers are also cannabis smokers, and a significant proportion of Cannabis smokers also use tobacco products LINK

> Research shows that young African American women smokers believe that little cigars, like the Swisher Sweets, are safer to smoke than cigarettes during pregnancy LINK
> Cannabis is widely believed to be safer than cigarettes by African American women LINK
> Highly contaminated black market Cannabis, as opposed to regulated and tested Cannabis, is disproportionately sold into the African American community LINK

8. There are no studies on the health impact of chronically inhaled pesticides through smoking
> Research on acute and chronic inhalation exposure events showing significant adverse outcomes focuses on agricultural, landscaping and pest control environments LINK
> None of the residue standards applied to legal cannabis are derived from medical or scientific inhalation studies – they are standards adapted largely from exposure studies on dermal contact or ingestion through foods and beverages. LINK

> Cannabis and Tobacco are the only consumable products that chronically expose the users and, if pregnant, their unborn children to multiple EDC pesticides by inhalation, yet the health consequences of such chronic inhalation exposure have never once been studied LINK

Fortunately, while the proposed demonstration will highlight the urgent need for such studies IT WILL NOT HAVE TO RELY ON ANY PRIOR RESEARCH to demonstrate effectively that eliminating inhaled pesticides alone is sufficient to move the needle on diabetic smokers’ numbers.

THE PROPOSED DEMONSTRATION

Please note: While I am submitting this initial proposal as an individual, if invited to make a full proposal then I will do so by teaming with an already-committed collaborator organization in the African American community that has 501.c.3 status and would be the fiscal sponsor, and we would collaborate in managing the project and conducting the proposed demonstrations.

The project will recruit and incentivize small cohorts of 10-20 volunteer diabetic African American female cannabis and cigarette smokers into 90 day trials in one or more communities. We will enroll volunteers who have shown motivation to manage their diabetes and who have demonstrated a desire to quit smoking but who have not succeeded.

A major obstacle to ‘quitting’ for diabetic women smokers is fear of weight gain, which this novel approach to harm reduction and diabetes self-management does not require.

The two groups in the demonstrations will be randomly assigned but not otherwise matched. They will agree to have their baseline biometric data clinically established. Group A will continue to use the cannabis they prefer, and will continue to smoke the cigarettes they prefer, and will be compensated in addition to their daily stipend for their expenses. All they have to do is keep smoking what they’re smoking, change nothing else in their diet or medications without recording it, and the program will pay for their smokes in return for them participating and being interviewed and clinically followed

Group B will commit that for 90 days they will smoke or vape only the tested, medical grade whole cannabis flower they are provided, and smoke only the USDA certified organic tobacco cigarettes they will also be provided. They will have a choice of cannabis varieties and will have a choice between manufactured commercial organic tobacco cigarettes and (volunteer) hand-rolled organic tobacco cigarettes. The hand-rolled cigarettes can be made from either mild or strong organic tobacco as desired, and menthol cigarette smokers in Group B will be offered an organic mentholated option to eliminate any difficulty they might have in adapting.

After the first 90 days, if they choose, Group A will receive Round 2 – 90 days of free organic cannabis and cigarettes like Group B received, so that they are not disadvantaged in realizing any potential health benefits and so that the project can gather additional data as well as the participants’ experiences.

Both groups will be paid a stipend to participate and to keep a daily record of their smoking amount and frequency, their medications, exercise, and diet. Their “numbers” will be personally and clinically monitored and they will also be asked to consent to be interviewed to record their ongoing personal non-clinical experiences during the 90 day transition away from inhaling pesticides. Changes in any related health issues like weight, breathing or pain and any associated data will also be monitored for the duration of the trial. Participants will also be asked to participate in follow-up Social Media campaigns to raise awareness of and share their stories of success with others.

Significant positive changes in the diabetic numbers for Group B compared with Group A, and then by Group A volunteers who go on to participate in Round 2, will demonstrate that providing Diabetic smokers with pesticide-free cannabis and tobacco improves their Diabetic status without their having to “quit smoking”, which is widely acknowledged as difficult and highly unlikely to succeed.

A successful outcome of even a single set of pesticide-free smoker experiences would challenge almost every assumption around smoking-related disease, and would offer a path to new, achievable, sustainable health benefits for diabetic African American women smokers along with other smokers.

One potential roadblock for diabetic smokers in marginalized communities being able to freely make these choices even with raised awareness could be lack of access to pesticide-free cannabis and tobacco, just as many people in marginalized communities can’t access, much less afford, the medicines, foods, and services they need. It is possible that innovative community-based medical cannabis non-profits and home-based grower cooperatives could provide access and affordability.

There would also be potential public health policy implications to a successful demonstration of this harm reduction option, including potentially making sense for organic cannabis and organic tobacco to be low-cost or zero copay prescription medicines as part of a broader economic and social cost management approach to smoking and health, diabetes, obesity and heart disease.

Pesticides and Diabetes

  1. Persistent Organic Pollutants and Type 2 Diabetes: A Critical Review of Review Articles
  2. Association between diabetes and pesticides: a case-control study among Thai farmers
  3. Exposure to pesticides and diabetes: A systematic review and meta-analysis
  4. Organochlorine Pesticide in Prediabetic & Newly Diagnosed Diabetes Mellitus Patients

Pesticides and Obesity

  1. Potential contribution of insecticide exposure and development of obesity and type 2 diabetes
  2. Association between maternal exposure to the pesticide DDT and risk of obesity in middle age
  3. Association between Exposure to p,p′-DDT and Its Metabolite p,p′-DDE with Obesity
  4. Grandmaternal Perinatal Serum DDT in Relation to Granddaughter Early Menarche and Adult Obesity: Three Generations in the Child Health and Development Studies Cohort

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